The best diagnostic test for paroxysmal nocturnal hemoglobinuria (PNH) is

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Hematology Final Exam Questions Pdf Questions

Question 1 of 5

The best diagnostic test for paroxysmal nocturnal hemoglobinuria (PNH) is

Correct Answer: D

Rationale: Flow cytometry (D) detecting GPI-anchored protein loss (e.g., CD55, CD59) is the gold standard for PNH, more specific than HAM (A), sucrose lysis (B), complement (C), or marrow study (E).

Question 2 of 5

Hereditary intrinsic factor deficiency (HIFD), formerly called congenital pernicious anemia, differs from the typical adult pernicious anemia by all the following EXCEPT

Correct Answer: D

Rationale: HIFD presents early (A), with normal acid (B), histology (C), and no antibodies (D), unlike adult PA. Lack of endocrine disorders (E) is true for both, as HIFD isn’t autoimmune.

Question 3 of 5

All the following conditions may be associated with iron deficiency EXCEPT

Correct Answer: B

Rationale: Hookworm (A), celiac (C), heart disease (D), and INH (E) cause iron loss or malabsorption. Prolonged hemolysis (B) leads to iron overload from transfusions, not deficiency.

Question 4 of 5

The main reason behind gamma irradiation of the blood products is to prevent

Correct Answer: C

Rationale: Gamma irradiation (C) inactivates lymphocytes in blood products, preventing GVHD in immunocompromised recipients, unlike bacterial (A), viral (B), allergic (D), or TRALI (E) risks.

Question 5 of 5

Spontaneous intracranial hemorrhage is more likely to occur in

Correct Answer: D

Rationale: Factor XIII deficiency (E) causes severe bleeding, including intracranial hemorrhage, due to unstable clots, more than factor VII (A), VIII (B), IX (C), or XI (D) deficiencies.

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