ATI RN
Microbiology Basic and Clinical Principles Test Bank Questions
Question 1 of 5
The bacteriological laboratory needs to prepare for analysis of materials that are suspected to be contaminated with spores of anthrax causative agent. What diagnostic preparation allows for quick detection of these spores?
Correct Answer: D
Rationale: The correct answer is D: Monoclonal antibodies to anthrax causative agent. Monoclonal antibodies are highly specific for detecting anthrax spores, providing quick and accurate results. They bind only to the anthrax causative agent, allowing for precise identification. Choice A (Anti-anthrax fluorescent serum) is incorrect because it is not as specific and sensitive as monoclonal antibodies. Choice B (Standard anthrax antigen) is incorrect as it is used to stimulate antibody production in the body, not for direct detection of spores. Choice C (Anti-anthrax immunoglobulin) is incorrect as it is a general term for antibodies and may not be specific to anthrax spores. In summary, monoclonal antibodies are the most suitable option for quick and accurate detection of anthrax spores due to their high specificity and sensitivity.
Question 2 of 5
A 12-year-old boy presents with nausea, frequent repeated vomiting that first occurred after eating canned vegetables. Objectively: the patient has dry mucous membranes, muscular hypotonia, anisocoria, mydriasis, dysphagia and dysarthria. What is the most likely diagnosis?
Correct Answer: A
Rationale: The most likely diagnosis is A: Botulism. The symptoms, such as nausea, vomiting after eating canned vegetables, dry mucous membranes, muscular hypotonia, anisocoria, mydriasis, dysphagia, and dysarthria, are classic signs of botulism poisoning. Botulism is caused by the neurotoxin produced by Clostridium botulinum bacteria found in improperly canned or preserved food. The neurotoxin affects the nervous system, leading to symptoms like those described. Shigellosis (B), Salmonellosis (C), and Cholera (D) typically present with different symptoms such as diarrhea, fever, and abdominal pain, which are not seen in this patient.
Question 3 of 5
A large-scale reaction with parapertussis and pertussis diagnosticums was made in order to make serological diagnostics of the whooping cough. At the bottom of the test-tubes with diagnosticum of Bordetella parapertussis a granular sediment formed. What antibodies did this reaction reveal?
Correct Answer: B
Rationale: The correct answer is B: Precipitins. When a granular sediment forms at the bottom of the test-tubes, it indicates the formation of antigen-antibody complexes that are insoluble and precipitate out of the solution. Precipitins are antibodies that specifically react with antigens to form insoluble complexes. Agglutinins cause clumping of cells, opsonins enhance phagocytosis, and bacteriolysins lyse bacteria. These processes do not result in the formation of a granular sediment, making them incorrect choices in this context.
Question 4 of 5
The Wasserman reaction is markedly positive (++++) in a 30-year-old man. What infectious disease is diagnosed using the Wasserman reaction?
Correct Answer: B
Rationale: The correct answer is B: Syphilis. The Wasserman reaction is a test for syphilis, specifically for detecting antibodies against the bacterium Treponema pallidum. In a 30-year-old man with a markedly positive Wasserman reaction, it indicates an active syphilis infection. Brucellosis (Choice A) is not diagnosed using the Wasserman reaction. Poliomyelitis (Choice C) is a viral infection affecting the spinal cord, not diagnosed using the Wasserman reaction. Influenza (Choice D) is a respiratory viral infection, not associated with the Wasserman reaction.
Question 5 of 5
A 30-year-old patient complains about having abdominal pain and diarrhea for five days; body temperature rise up to 37, 5oC along with chills. The day before a patient had been in a forest and drunk from an open water reservoir. Laboratory analyses enabled to make the following diagnosis: amebic dysentery. What is the drug of choice for its treatment?
Correct Answer: A
Rationale: The correct answer is A: Metronidazole. Rationale: 1. Metronidazole is the drug of choice for amebic dysentery due to its effectiveness against the causative agent, Entamoeba histolytica. 2. Metronidazole has good tissue penetration and is able to reach the site of infection in the gut. 3. It is a bactericidal drug that acts by disrupting the DNA structure of the parasite. 4. Metronidazole is well-absorbed orally and has minimal side effects. Summary of other choices: B: Furazolidonum - Not the drug of choice for amebic dysentery. It is primarily used for treating bacterial diarrhea. C: Levomycetin - Not effective against Entamoeba histolytica and not recommended for amebic dysentery. D: Phthalazol - Not commonly used for amebic dysentery treatment. Metronidazole is preferred due