Correct Answer: C

Rationale: The correct answer is C: Staphylococcus saprophyticus. The rationale is that Staphylococcus saprophyticus is the only one among the listed species that is known to be resistant to novobiocin. This resistance is due to the specific mechanism of action of novobiocin, which targets DNA gyrase, and Staphylococcus saprophyticus possesses an altered DNA gyrase enzyme that renders it resistant to the antibiotic. Staphylococcus aureus and Staphylococcus epidermidis are susceptible to novobiocin, making choices A and B incorrect. Choice D, "none of the listed," is also incorrect as Staphylococcus saprophyticus is indeed resistant to novobiocin.

Correct Answer: B

Rationale: The correct answer is B: serratia spp. This is because serratia spp. are not typically found in the normal skin microflora. Normal skin microflora primarily consist of bacteria such as diphtheroids, alpha-hemolytic streptococci, and epidermidis. Serratia spp. are more commonly associated with healthcare-associated infections rather than being a part of the skin's natural bacterial flora. Therefore, choice B is the correct answer. Choices A, C, and D are incorrect as they are commonly found in the normal skin microflora.

Correct Answer: A

Rationale: The correct answer is A: Nystatin. Nystatin is an antifungal medication specifically used to treat candida infections. It works by disrupting the cell membrane of the fungus, leading to its death. Penicillin (B) is an antibiotic effective against bacterial infections, not fungal. Streptomycin (C) is also an antibiotic used for bacterial infections. Isoniazid (D) is used to treat tuberculosis, not candida infections. Therefore, Nystatin is the best choice for treating candida infections due to its antifungal properties.

Correct Answer: D

Rationale: The correct answer is D. Escherichia coli, Salmonella enterica, and Pseudomonas aeruginosa all produce endotoxins that can lead to septic shock. Endotoxins are components of the outer membrane of Gram-negative bacteria that can trigger a systemic inflammatory response, potentially leading to septic shock. E. coli and Salmonella are common causes of bacterial infections that can result in septic shock, while P. aeruginosa is known for causing infections in immunocompromised individuals. Therefore, since all three bacteria produce endotoxins that can lead to septic shock, the correct answer is D.Choices A, B, and C are incorrect because each of these bacteria individually produces endotoxins that can contribute to septic shock.

Correct Answer: B

Rationale: The correct answer is B, Antony van Leeuwenhoek. He was the first to observe and describe "animalcules" (microorganisms) through his early microscopes. Robert Hooke (A) is known for his work with cells but did not discover animalcules. Hans Janssen (C) and John Needham (D) did not make significant contributions to the discovery of microorganisms. Leeuwenhoek's pioneering observations were crucial in the development of microbiology.