ATI RN
Pediatric Immunization NCLEX Questions Questions
Question 1 of 5
The aim of monoclonal antibody production is to produce cells that only secrete immunoglobulin directed against the antigen used in immunization. Which of the following hybridoma production steps is NOT correct?
Correct Answer: C
Rationale: Selective medium (e.g., HAT) allows only fused hybridoma cells to survive, not non-fused cells, making c incorrect.
Question 2 of 5
Penicillin can form a hapten-carrier conjugate with a self-protein that can then act as an immunogen and generate an immunoglobulin antibody, and can cross-react with a number of other antibiotics. This can complicate the treatment of bacterial infections in these patients because they are unable to take the antibiotics necessary to combat the infection.
Correct Answer: C
Rationale: This describes an IgE-mediated allergic response, where penicillin cross-reacts, causing hypersensitivity.
Question 3 of 5
Each polypeptide chain (heavy and light) on immunoglobulin has a variable (V) and constant (C) region. Immunoglobulin chains are encoded by that is/are rearranged during development to assemble a functional gene encoding either a heavy or a light chain.
Correct Answer: C
Rationale: Immunoglobulin genes in B cells are encoded by sets of V, D, and J gene segments that rearrange during development.
Question 4 of 5
If alternative processing uses the second polyadenylation site, then what type of heavy chain mRNA is derived?
Correct Answer: C
Rationale: Using the second polyadenylation site results in δ (delta) heavy chain mRNA, encoding IgD.
Question 5 of 5
Which of the following TCR genetic chains contain D-segments, similar to immunoglobulin heavy chains?
Correct Answer: C
Rationale: Beta (β) and delta (δ) chains contain D-segments, similar to immunoglobulin heavy chains.