The 47,XXX (trisomy) chromosomal constitution is the most frequent extra-X chromosome abnormality in females, occurring in almost 1 in 1,000 liveborn females. It is characterized by the following EXCEPT

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Pediatric Endocrine System Questions

Question 1 of 5

The 47,XXX (trisomy) chromosomal constitution is the most frequent extra-X chromosome abnormality in females, occurring in almost 1 in 1,000 liveborn females. It is characterized by the following EXCEPT

Correct Answer: C

Rationale: 47,XXX females typically have normal sexual development (not delayed, C).

Question 2 of 5

Any child with diabetic ketoacidosis (DKA) can be easily transitioned to oral intake and subcutaneous insulin when the following criteria are found EXCEPT

Correct Answer: B

Rationale: Transition requires pH >7.30 (not 7.25, B) to ensure acidosis resolution.

Question 3 of 5

Guidelines suggest that diabetic patients should commence screening for celiac disease

Correct Answer: A

Rationale: Celiac screening is recommended at diagnosis (A) for T1DM due to high co-prevalence.

Question 4 of 5

When diabetes and thyroid disease coexist, the possibility of autoimmune adrenal insufficiency should be considered. It may be heralded by the followings EXCEPT

Correct Answer: A

Rationale: Increasing insulin requirements (A) suggest better insulin sensitivity, not adrenal insufficiency, which reduces insulin needs.

Question 5 of 5

You suspect a metabolic problem in a 30-day-old girl presented with poor feeding, vomiting, lethargy, and convulsion. Previous sibling died with the same condition. Serum ammonia, pH, HCO3, and anion gap are normal. Of the following, the MOST likely diagnosis is

Correct Answer: D

Rationale: Normal ammonia, pH, and anion gap with neonatal symptoms and family history suggest an aminoacidopathy (e.g., nonketotic hyperglycinemia), not porphyria (A), galactosemia (B), organic acidemia (C), or urea cycle defect (D), which alter these parameters.

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