Systemic corticosteroid therapy is not used routinely and is reserved only for severe cases of:

Correct Answer: B

Rationale: Systemic corticosteroid therapy is indicated in posterior uveitis due to its potent anti-inflammatory properties, helping to reduce inflammation in the eye. For exfoliative dermatitis, topical corticosteroids are more commonly used. Acute rheumatic fever is treated with antibiotics and anti-inflammatory medications. Hodgkin's disease requires chemotherapy and radiation therapy. Therefore, the correct answer is B as systemic corticosteroids are specifically beneficial in managing inflammation in posterior uveitis.

Correct Answer: D

Rationale: The correct answer is D: Precocious puberty. Parenteral testosterone therapy can suppress endogenous testosterone production, delaying puberty rather than causing precocious puberty. Gynaecomastia (A), acne (B), and cholestatic jaundice (C) are possible adverse effects of testosterone therapy due to its impact on hormone levels and liver function. However, precocious puberty is not a known side effect of testosterone therapy in boys.

Correct Answer: D

Rationale: The correct answer is D: Hot flashes. Danazol is a synthetic androgen that suppresses ovarian function, leading to amenorrhea and decreased estrogen levels. This mechanism of action makes it unlikely to cause hot flashes, which are commonly associated with estrogen fluctuations. Acne (Choice A), menorrhagia (Choice B), and amenorrhea (Choice C) are potential side effects of Danazol due to its hormonal effects on the body.

Correct Answer: A

Rationale: The correct answer is A: Danazol. Danazol is a synthetic androgen that suppresses gonadotropin secretion, leading to elevated testosterone levels. Finasteride inhibits 5-alpha-reductase, reducing dihydrotestosterone levels. Flutamide is an androgen receptor antagonist, lowering testosterone levels. Ketoconazole inhibits steroid synthesis, decreasing testosterone production. Therefore, only Danazol directly increases circulating testosterone levels in men.

Correct Answer: B

Rationale: Estrogen therapy in postmenopausal women decreases the risk of osteoporosis by preserving bone density. Estrogen deficiency after menopause is a major risk factor for osteoporosis. The increased risk of gall stones, endometrial carcinoma, and breast cancer are associated with estrogen therapy due to its effects on bile composition, endometrial cell proliferation, and breast tissue growth, respectively. Therefore, the correct answer is B as estrogen therapy actually helps prevent osteoporosis in postmenopausal women.