Sudden withdrawal of glucocorticoids after prolonged therapy results in:

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Introduction to the Pharmacology of CNS Drugs Questions

Question 1 of 5

Sudden withdrawal of glucocorticoids after prolonged therapy results in:

Correct Answer: B

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Question 2 of 5

A 12-year-old with newly diagnosed type I diabetes mellitus has ketoacidosis. Serum potassium level 3.5 mmol/L and PH 7.2. What are the lines of treatment?

Correct Answer: C

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Question 3 of 5

A patient with severe shoulder pain resulting from inflammation is not responding to treatment with naproxen. You elect to begin a course of treatment with oral dexamethasone. What is the basis that the glucocorticoid will be more effective as an anti-inflammatory agent?

Correct Answer: A

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Question 4 of 5

Men who use large doses of anabolic steroids are at increased risk of:

Correct Answer: D

Rationale: Large doses of anabolic steroids (choice D) risk liver toxicity, including cholestatic jaundice and elevated AST, due to hepatic metabolism and 17-alpha-alkylated forms. Anemia (choice A) isn't typical (erythrocytosis occurs), testicular enlargement (choice B) reverses to atrophy, and hirsutism (choice C) is female-specific. Liver damage is a serious concern, necessitating monitoring in steroid abuse scenarios.

Question 5 of 5

A 58 year-old postmenopausal woman has low bone mineral density. Chronic use of which of the following medications is most likely to have contributed to this woman's osteoporosis?

Correct Answer: C

Rationale: Prednisone (choice C), a glucocorticoid, contributes to osteoporosis by inhibiting osteoblasts and increasing resorption, a common chronic use effect. Lovastatin (choice A), Metformin (choice B), and Propranolol (choice D) don't significantly affect bone density. Prednisone's impact is well-documented.

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