ATI RN
Pediatric Immunizations NCLEX Questions Questions
Question 1 of 5
Somatic hypermutation in the Immunoglobulin (Ig) variable region occurs...?
Correct Answer: C
Rationale: Somatic hypermutation occurs in B cells during their mitosis and differentiation in the bone marrow or lymphoid tissues, enhancing antibody affinity.
Question 2 of 5
Matching: Complement deficiency - Recurrent neisserial infection
Correct Answer: A
Rationale: Deficiencies in C5, C6, C7, C8, or C9 impair the membrane attack complex, leading to recurrent Neisseria infections (e.g., meningococcus). Properdin stabilizes the alternative pathway but is less directly linked to neisserial susceptibility compared to terminal complement deficiencies.
Question 3 of 5
Matching: Immunodeficiency - High frequency of autoimmune disorders
Correct Answer: C
Rationale: CVID is associated with a high frequency of autoimmune disorders due to immune dysregulation.
Question 4 of 5
The X-linked lymphoproliferative (XLP) syndrome is classically associated with overwhelming infection with which organism?
Correct Answer: A
Rationale: XLP is classically linked to severe, often fatal Epstein-Barr virus infections due to defective immune regulation.
Question 5 of 5
Repeated meningococcal infections suggest what type of immune disorder?
Correct Answer: D
Rationale: Repeated meningococcal infections suggest a complement deficiency, particularly terminal components (C5-9), impairing bacterial lysis.