Soil microflora often includes the representatives of pathogenic microorganisms. Specify the diseases, whose causative agents may say viable in the soil for a long time:

Correct Answer: B

Rationale: The correct answer is B: Tuberculosis and mycobacterioses. Mycobacterium tuberculosis, the causative agent of tuberculosis, and other mycobacteria can survive in the soil for extended periods. Here's the rationale: 1. Mycobacteria have a waxy cell wall that provides resistance to harsh environmental conditions. 2. The slow growth rate of mycobacteria allows them to persist in the soil for long periods. 3. Tuberculosis and mycobacterioses are known to be transmitted through environmental exposure, including soil. 4. Colibacillosis and cholera (Choice C) are caused by enteric bacteria that do not survive well in soil. 5. Leptospirosis and plague (Choice D) are bacterial diseases transmitted through animal hosts and are not known to be soil-borne.

Correct Answer: A

Rationale: The correct answer is A: Pseudomonas aeruginosa. Pseudomonas aeruginosa is known to produce green colonies on Endo agar due to its pyoverdin pigment. It is also a Gram-negative rod. P. aeruginosa commonly causes respiratory infections in immunocompromised patients. Escherichia coli (B) typically produces pink colonies on Endo agar and is more associated with gastrointestinal infections. Salmonella typhi (C) and Shigella dysenteriae (D) are both Enterobacteriaceae that usually do not produce green colonies on Endo agar and are more associated with gastrointestinal infections as well.

Correct Answer: D

Rationale: The correct answer is D: Granulomatosis. The appearance of a 10 mm papule 48 hours after the Mantoux test indicates a delayed-type hypersensitivity reaction, which is characteristic of granulomatosis. This type of reaction involves activation of macrophages and T cells, leading to the formation of granulomas. Granulomas are organized collections of immune cells that wall off the antigen, in this case, the tuberculin antigen. A, B, and C are incorrect: A: Cellular cytotoxicity involves the destruction of target cells by immune cells such as cytotoxic T cells or natural killer cells. This mechanism is not associated with the delayed-type hypersensitivity reaction seen in granulomatosis. B: Anaphylaxis is a rapid and severe allergic reaction involving IgE-mediated release of histamine and other inflammatory mediators. This is not the mechanism underlying the delayed-type hypersensitivity reaction in the Mantoux test. C: Antibody-dependent cytotoxic

Correct Answer: C

Rationale: Step 1: Anthrax causative agent is Bacillus anthracis, which forms spores. Step 2: Spores are highly resistant structures that can survive for a long time. Step 3: These spores can germinate into active bacteria when conditions are favorable. Step 4: The presence of spores in the powder makes it dangerous even long after being mailed. Summary: A: Incorrect - Anthrax does not form a protein capsule. B: Incorrect - Anthrax does not form a polysaccharide capsule. C: Correct - Anthrax forms spores that are highly resistant. D: Incorrect - Anthrax does not form flagella.

Correct Answer: D

Rationale: The correct answer is D: active transport system. Permeases are specific carriers that actively transport molecules across a cell membrane against their concentration gradient, requiring energy input. This process is known as active transport, which is essential for maintaining cellular homeostasis and allowing the cell to accumulate specific molecules. Facilitated diffusion (A) and passive transport (B) both involve the movement of molecules down their concentration gradient without the need for energy input. Simple diffusion (C) also does not involve specific carriers and relies on the natural movement of molecules from areas of high concentration to low concentration. Therefore, the correct choice is D as permeases specifically function in active transport systems.

Correct Answer: C

Rationale: The correct answer is C: Janssen. In the 16th century, Hans and Zacharias Janssen were a father-and-son team from the Netherlands who are credited with inventing the compound microscope. They constructed a simple tube with lenses at each end, which allowed for magnification of small objects. Their invention significantly contributed to the development of microscopy. Van Leeuwenhoek is known for his contributions to microscopy but did not invent the compound microscope. Semmelweis is known for his work in handwashing and preventing infection. Hooke made significant contributions to microscopy but did not invent the compound microscope.

Correct Answer: D

Rationale: The correct answer is D: salmonellosis. Zoonotic diseases are those that can be transmitted from animals to humans. Salmonella is not directly transmitted from animals to humans, instead, it is typically transmitted through contaminated food or water. Brucellosis (A), undulant fever (B), and plague (C) are all zoonotic diseases that can be directly transmitted from animals to humans through various means. Therefore, salmonellosis does not fit the definition of a zoonotic disease, making it the correct answer.

Correct Answer: A

Rationale: The correct answer is A: Meningitides. H. Influenzae type b (Hib) is a bacterium known to cause meningitis, a serious infection of the protective membranes covering the brain and spinal cord. Hib does not typically cause tonsillitis, urinary tract infections, or gastroenteritis. Meningitis is a life-threatening condition that requires prompt treatment, making it crucial to identify Hib as the causative agent.

Correct Answer: D

Rationale: Step-by-step rationale for why answer D is correct: 1. Tetanus exotoxins are produced by Clostridium tetani bacteria. 2. Once formed, the exotoxins can spread through the bloodstream. 3. Retrograde axonal transport allows the exotoxins to travel to the central nervous system (CNS). 4. In the CNS, the exotoxins can cause the symptoms of tetanus. 5. Options A, B, and C are incorrect as tetanus exotoxins do not follow those pathways. In summary, option D is correct as tetanus exotoxins can spread through the blood and reach the CNS via retrograde axonal transport, while the other options do not align with the known pathophysiology of tetanus.