ATI RN
The Cardiovascular Pharmacology of Nonsteroidal Anti-Inflammatory Drugs Questions
Question 1 of 5
Side effects of indometacin include the following:
Correct Answer: D
Rationale: The correct answer is D: All of the above. Indometacin is a nonsteroidal anti-inflammatory drug known to cause various side effects. A: Abdominal pain, diarrhea, gastrointestinal hemorrhage, and pancreatitis are common gastrointestinal side effects of indometacin. B: Dizziness, confusion, and depression are known central nervous system side effects of indometacin. C: Thrombocytopenia, a decrease in platelet count, is a potential hematological side effect of indometacin. Therefore, all the listed side effects are associated with indometacin, making option D the correct answer. Other choices are incorrect as they do not encompass the full range of side effects associated with indometacin.
Question 2 of 5
Which of the following antivitamins prevent a vitamin A from exerting its typical metabolic effects?
Correct Answer: A
Rationale: The correct answer is A: Lipooxidase. Antivitamins are substances that interfere with the absorption, metabolism, or utilization of vitamins. In this case, antivitamin A would prevent vitamin A from exerting its typical effects. Lipooxidase is an antivitamin that inhibits the action of vitamin A by interfering with its metabolic pathways. Summary: - Oral contraceptives do not prevent vitamin A from exerting its effects. - Antibiotics do not prevent vitamin A from exerting its effects. - Therefore, the correct answer is A: Lipooxidase.
Question 3 of 5
When used alone, the bile acid-binding resins are contraindicated in patients with hypertriglyceridemia. This consideration is:
Correct Answer: A
Rationale: The correct answer is A: TRUE. Bile acid-binding resins can worsen hypertriglyceridemia by increasing triglyceride levels. This is due to the compensatory increase in hepatic triglyceride synthesis. Choice B is incorrect because it contradicts this established fact. Choice C is incorrect as it implies all options are true, which is not the case. Choice D is incorrect as it suggests that none of the options are true, which is also not accurate.
Question 4 of 5
Route of administration of dihydrotachysterol is:
Correct Answer: C
Rationale: The correct answer is C: Oral. Dihydrotachysterol is a form of vitamin D used to treat hypoparathyroidism. The oral route is chosen for its optimal absorption in the gastrointestinal tract. Intravenous (A) and subcutaneous (B) routes are not commonly used for dihydrotachysterol administration due to potential adverse effects and lack of significant benefits. Intranasal (D) administration is not suitable for dihydrotachysterol as it is not designed to be absorbed through the nasal mucosa.
Question 5 of 5
The drug has a steroid-like structure which is responsible for its anti-androgenic effect:
Correct Answer: D
Rationale: The correct answer is D: Spironolactone (Aldactone). Spironolactone has a steroid-like structure due to its chemical similarity to aldosterone, allowing it to competitively inhibit aldosterone receptors. This anti-androgenic effect is crucial in conditions like hirsutism and acne. Amiloride (A), Furosemide (B), and Hydrochlorothiazide (C) do not possess a steroid-like structure and do not exhibit anti-androgenic properties.