Serious side effects of metamizole (analgin) include the following:

Correct Answer: A

Rationale: The correct answer is A. Metamizole use is associated with serious side effects such as agranulocytosis and aplastic anemia. Agranulocytosis is a severe decrease in white blood cells, leading to increased risk of infections. Aplastic anemia is a condition where the bone marrow does not produce enough blood cells. Choices B and C are incorrect as they are not known side effects of metamizole. Salicylism is associated with aspirin toxicity, while iatrogenic Cushing's syndrome is typically caused by prolonged use of glucocorticoids, not metamizole. Therefore, the correct choice is A as it accurately reflects the serious side effects of metamizole.

Correct Answer: D

Rationale: The correct answer is D: All of the above. Isoniazide, ethanol, and carbamazepine are all antivitamins that interfere with the metabolism of vitamin B6. Isoniazide inhibits the conversion of vitamin B6 to its active form, ethanol decreases the absorption and utilization of vitamin B6, and carbamazepine reduces the plasma levels of vitamin B6. Therefore, all three choices prevent vitamin B6 from exerting its metabolic effects. The other choices are incorrect because each of them individually interferes with the action of vitamin B6.

Correct Answer: A

Rationale: The correct answer is A: TRUE. Bile acid-binding resins can bind to various drugs and vitamins in the gastrointestinal tract, leading to reduced absorption. This occurs due to the resins' ability to form complexes with these substances, preventing their uptake into the bloodstream. This interference can potentially impact the effectiveness of medications or the absorption of essential vitamins. Choices B, C, and D are incorrect because they do not accurately reflect the specific mechanism of action of bile acid-binding resins in drug and vitamin absorption.

Correct Answer: A

Rationale: The correct answer is A: Hepatic toxicity. Dihydrotachysterol is a vitamin D analog used to treat hypoparathyroidism and hypocalcemia. It can cause liver damage as a side effect due to its metabolism in the liver. General malaise (B), lymphocytopenia (C), and hypertension (D) are not typically associated with dihydrotachysterol use. Therefore, the correct answer is A based on the drug's mechanism of action and known side effects.

Correct Answer: C

Rationale: Rationale: Chronic use of Furosemide can lead to distal tubular hypertrophy, reducing its diuretic effect due to compensatory changes in the nephron function. Furosemide is a loop diuretic acting in the thick ascending limb of the loop of Henle. Acetazolamide is a carbonic anhydrase inhibitor acting in the proximal tubule. Amiloride is a potassium-sparing diuretic acting on the collecting duct. Hydrochlorothiazide is a thiazide diuretic acting in the distal convoluted tubule. Only Furosemide among the options affects the loop of Henle, leading to distal tubular hypertrophy over time.