Rheumatoid factor (RF)-positive polyarthritis usually accounts for <10% of all juvenile idiopathic arthritis (JIA) cases. The articular manifestation pattern is characterized by involvement of 25 joints in both upper and lower extremities. Of the following, the LEAST effective drug to induce remission for this subtype of JIA is

Correct Answer: A

Rationale: NSAIDs provide symptomatic relief but are not effective in inducing remission in severe polyarticular JIA.

Correct Answer: D

Rationale: Osler's nodes are painful, tender nodules found on fingers and toes, caused by immune complex deposition in infective endocarditis.

Correct Answer: D

Rationale: Stage II-B indicates involvement of two or more lymph node regions on the same side of the diaphragm with systemic symptoms like fever or weight loss.

Correct Answer: C

Rationale: Early septic shock causes distributive shock due to widespread vasodilation and increased capillary permeability, leading to low systemic vascular resistance.

Correct Answer: B

Rationale: Renal tubular acidosis causes normal anion gap acidosis because it results from impaired renal acid excretion rather than accumulation of organic acids.