ATI RN
Pediatrics Genetics Questions
Question 1 of 5
RET gene:
Correct Answer: D
Rationale: RET (proto-oncogene) gain-of-function mutations drive cancers (e.g., MEN2) via anti-apoptotic and proliferative effects. Loss of function causes Hirschsprung disease.
Question 2 of 5
Tetraploidy:
Correct Answer: D
Rationale: Tetraploidy means four complete sets of chromosomes. Normal diploid humans have 46 chromosomes (2n=46); tetraploidy is 4n=92.
Question 3 of 5
Which of the following chromosomal alterations would you expect to have the most drastic consequences?
Correct Answer: D
Rationale: Deletion removes genetic material, often causing severe effects due to loss of gene function, unlike inversions or translocations (which may be balanced) or duplications (adding material).
Question 4 of 5
Heart disease, diabetes, cancer, alcoholism and many mental illnesses can best be described as:
Correct Answer: C
Rationale: These conditions result from multiple genetic and environmental factors, often involving many genes (polygenic) and lifestyle influences.
Question 5 of 5
Which of the following is correct with regard to aneuploidy?
Correct Answer: B
Rationale: Aneuploidy is an abnormal chromosome number, e.g., 2n+1 (trisomy, 47 chromosomes). Inversions are structural, 4n is polyploidy, and not all aneuploids die.