Researches from the Cleveland Clinic (OH, USA) found that a microbiome present in breast tissue may be associated with breast cancer (Oncotarget 2017; 8:88122-88138). They hope to find a biomarker which help in fast and easy breast cancer diagnosis. Let us assume that they have already found such an biomarker and prepared a diagnostic test for detecting its presence. Using this test they examined 100 women with breast cancer and 100 healthy women who were diagnosed with other methods. They obtained the following results: Indicate the false interpretation of those results:

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Public Health Foundations Questions

Question 1 of 5

Researches from the Cleveland Clinic (OH, USA) found that a microbiome present in breast tissue may be associated with breast cancer (Oncotarget 2017; 8:88122-88138). They hope to find a biomarker which help in fast and easy breast cancer diagnosis. Let us assume that they have already found such an biomarker and prepared a diagnostic test for detecting its presence. Using this test they examined 100 women with breast cancer and 100 healthy women who were diagnosed with other methods. They obtained the following results: Indicate the false interpretation of those results:

Correct Answer: B

Rationale: Specificity = TN / (TN + FP) = 89 / (89 + 11) = 89%, not 11%. Thus, B is false.

Question 2 of 5

In a population of 1.000.000 inhabitants 1.000 persons suffer from pancreatic cancer and in this population there were 200 deaths from that disease in one calendar year. Which of the following is the best overall measure of the described epidemiological situation with regard to pancreatic cancer?

Correct Answer: D

Rationale: Case fatality rate = (deaths / cases) = 200 / 1000 = 20% or 200/1000, best reflecting the disease’s lethality.

Question 3 of 5

A population-based screening of breast cancer was performed using mammography. The sensitivity of the diagnostic tool was 90%, and its specificity was 95%. As a result it can be estimated that in the examined population:

Correct Answer: A

Rationale: Specificity = 95%, so 5% of healthy individuals get false positives.

Question 4 of 5

Factors which influence health according to Lalonde's concept do not include:

Correct Answer: D

Rationale: Lalonde’s model includes environment, biology (genetics), lifestyle, and healthcare; financial factors are indirect.

Question 5 of 5

On a medical statement form confirming temporary incapacity for work or a stay in a stationary healthcare institution (ZUS ZLA form) A code means incapacity for work:

Correct Answer: D

Rationale: In Poland’s ZUS system, code A denotes incapacity due to alcohol abuse.

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