ATI RN
Pharmacology ATI Proctored Exam 2024 Questions
Question 1 of 5
Regarding NSAIDS:
Correct Answer: D
Rationale: At high doses, aspirin shifts to zero-order kinetics, not first-order, due to saturated metabolism, so that's false. Aspirin irreversibly inhibits COX, not reversibly, distinguishing it from other NSAIDs, making that false. At low doses (≤2 g/day), aspirin retains uric acid, not reduces it (uricosuric at >4 g/day), so that's incorrect. All NSAIDs, including aspirin and ibuprofen, distribute into synovial fluid with repeated dosing, a true statement, aiding arthritis treatment. Combining ibuprofen and aspirin reduces, not increases, efficacy due to competition. Synovial penetration is key to their anti-inflammatory action in joints.
Question 2 of 5
Which statement regarding medication distribution within the body is accurate?
Correct Answer: C
Rationale: Lipid-soluble drugs distribute widely, crossing membranes like the blood-brain barrier easily, unlike water-soluble ones. The barrier blocks some, not all, drugs. High blood flow aids delivery, not hinders. Protein complexes limit free drug, not enable crossing. Lipid solubility enhances distribution, a pharmacokinetic truth.
Question 3 of 5
The patient has been taking lorazepam (Ativan) for 2 years. The patient stopped this medication after a neighbor said the drug manufacturer's plant was contaminated with rat droppings. What best describes the nurse's assessment of the patient when seen 3 days after stopping his medication?
Correct Answer: A
Rationale: Abruptly stopping lorazepam, a benzo, after 2 years triggers withdrawal-tachycardia, fever, cramps-due to GABA downregulation, per pharmacology. It's not safe-dependence forms. Opioid-like symptoms (pupils, constipation) don't fit. Calmness contradicts withdrawal. These signs reflect cessation risk, needing taper.
Question 4 of 5
The nurse administers calcium intravenously (IV) to the client. What will a key assessment by the nurse include?
Correct Answer: B
Rationale: IV calcium risks infiltration-site assessment (e.g., swelling) ensures safety, per protocol. Glucose/potassium aren't directly tied-edema is secondary. Site check prevents complications, per administration.
Question 5 of 5
A 16-year-old female was rescued from a house fire and transported to the emergency department. She has no serious burns but is beginning to show signs of cyanide toxicity. She is given sodium nitrite as an antidote. How will sodium nitrite help in this case?
Correct Answer: D
Rationale: Cyanide toxicity from smoke inhalation blocks cytochrome oxidase. Sodium nitrite oxidizes hemoglobin iron to methemoglobin, which binds cyanide, reducing toxicity. Urine pH , chelation , inactivation , and enzyme regeneration (E) don't apply. This shifts cyanide away from mitochondria, aiding recovery.