ATI RN
Introduction to Pharmacology ATI Quizlet Questions
Question 1 of 5
Regarding calcium channel blockers:
Correct Answer: C
Rationale: All calcium channel blockers (CCBs) like verapamil and nifedipine are orally active, so that's false. Half-lives vary (e.g., nifedipine ~2-5 hours, diltiazem longer), not uniformly 8-12 hours, making that false. They block L-type voltage-gated calcium channels, reducing vascular and cardiac contractility, a true statement. They relax bronchiolar smooth muscle, not unaffected, so that's false. Dihydropyridines cause reflex tachycardia, not bradycardia. The L-type blockade is their unifying mechanism, key to antihypertensive and antianginal effects.
Question 2 of 5
Indicate the spot of the median effective dose on the frequency distribution curve.
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 3 of 5
Which drug category can be used for treating anxiety?
Correct Answer: C
Rationale: Seizure drugs (e.g., benzodiazepines like clonazepam) treat anxiety via GABA enhancement, calming overactivity, per pharmacology. Antitussives suppress cough, anticoagulants thin blood, and antibiotics fight infection-none target anxiety. Seizure drugs' anxiolytic use is established, fitting the need.
Question 4 of 5
A 45-year-old woman has just received a kidney transplant. She is placed on several immunosuppressants to prophylactically prevent her body rejecting the donor organ. Which of the following immunosuppressants interferes with T-cell activation by modifying the activity of calcineurin?
Correct Answer: A
Rationale: Post-kidney transplant, immunosuppression prevents rejection by targeting T-cell activation. Cyclosporine binds calcineurin, inhibiting its phosphatase activity, which blocks IL-2 transcription, crucial for T-cell proliferation-making it the correct answer. Methotrexate inhibits purine synthesis, affecting rapidly dividing cells, not calcineurin. Prednisolone , a corticosteroid, suppresses inflammation broadly but doesn't target calcineurin. Sirolimus inhibits mTOR, a different pathway, affecting T-cell proliferation downstream, not calcineurin. Temsirolimus (E) is similar to sirolimus. Cyclosporine's specificity to calcineurin aligns with the question's focus, a cornerstone in transplant regimens. Its mechanism disrupts early T-cell signaling, critical for alloimmune responses, unlike the broader or alternative actions of other options. This precision ensures effective prophylaxis while distinguishing it from other immunosuppressants in the list.
Question 5 of 5
A 48-year-old man with a known history of asthma takes daily theophylline. He is found unconscious in his bathroom with an open bottle of theophylline that is now empty nearby. He is found by EMS to be apneic and pulseless. What is the most likely cause of death in this patient?
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.