ATI RN
Quizlet Pharmacology ATI Questions
Question 1 of 5
Regarding biotransformation, which of the following is true:
Correct Answer: B
Rationale: Ethanol competes with methanol metabolism, not enhances it, increasing toxicity, so that's false. Grapefruit juice inhibits CYP3A4, reducing cyclosporin metabolism, raising levels, a true statement critical for transplant patients. Phenytoin induces, not inhibits, theophylline metabolism, lowering levels. Rifampicin induces, not inhibits, oral contraceptive metabolism, reducing efficacy. Griseofulvin induces warfarin metabolism, not inhibits. Grapefruit juice's effect is a classic drug-food interaction, necessitating dose adjustments or avoidance.
Question 2 of 5
Which organ is the most responsible for the first-pass effect?
Correct Answer: C
Rationale: The liver, via portal vein metabolism, drives the first-pass effect, reducing oral drug bioavailability (e.g., morphine) before systemic circulation. Bladder and kidneys excrete, not metabolize first. Stomach degrades some, but liver's enzyme activity dominates. First-pass is liver-centric, shaping dosing.
Question 3 of 5
The patient comes to the emergency department after an overdose of lorazepam (Ativan). The nurse will plan to administer which medication?
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 4 of 5
The client receives alendronate (Fosamax) as treatment for osteoporosis. Which symptoms, caused by an adverse effect of the medication, does the nurse teach should be reported to the physician?
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
A 37-year-old man is found to have hypercholesterolemia during a routine checkup. The physician prescribes lovastatin and counsels the patient to make healthy dietary and lifestyle changes to keep his cholesterol under control. Two weeks later, he returns complaining of severe muscle pain, possibly caused by his lovastatin therapy. He insists that he is taking the medication exactly as prescribed, but the physician knows that lovastatin is metabolized by the cytochrome P450 3A4. What else may he be using that would explain his condition?
Correct Answer: B
Rationale: Lovastatin's myopathy (muscle pain) suggests a CYP3A4 interaction. Grapefruit juice inhibits CYP3A4, increasing lovastatin levels, causing toxicity. Barbiturates , Griseofulvin , and Phenytoin induce CYP3A4, reducing levels. St. John's wort (E) also induces. Grapefruit juice fits the timeline and mechanism, explaining the adverse effect.