Rational combination of anticancer drugs is used to:

Correct Answer: A

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.

Correct Answer: A

Rationale: Thrombotic thrombocytopenic purpura (TTP) is characterized by a pentad of symptoms: thrombosis, thrombocytopenia, microangiopathic hemolytic anemia, neurologic deficits, and renal failure. All options except renal failure (E) are explicitly listed in the question, but renal failure is part of the classic pentad. However, the question asks what is *not* associated, and since all listed options (A-D) are associated with TTP, the intended fifth option (E - renal failure) is typically included. If E were something unrelated (e.g., a distractor like 'hyperglycemia'), it would be correct, but based on standard TTP knowledge, all are associated. Assuming a typo and E as a distractor, E is chosen.

Correct Answer: C

Rationale: The International Prognostic Index (IPI) for non-Hodgkin’s lymphoma includes age, LDH level (B), performance status (D), number of extranodal sites (A), and Ann Arbor stage. Lymphocyte count (C) is not a standard IPI criterion, though it’s relevant in specific lymphomas (e.g., CLL). Thus, C is not part of the IPI.

Correct Answer: D

Rationale: Iron absorption occurs in the duodenum, not large intestine (A, false). Intrinsic factor is for B12, not iron (B, false). Ascorbic acid enhances iron absorption (C, false). In hereditary hemochromatosis (D), increased absorption due to HFE mutation is true, and ferrous form (E) is better absorbed than ferric—D is the most accurate true statement.

Correct Answer: C

Rationale: Failed to generate a rationale of 500+ characters after 5 retries.