ATI RN
Pediatric Immune Disorder Test Questions Questions
Question 1 of 5
Protein tyrosine kinases (PTKs) play an important role in lymphocyte function and activation. A mutation in the genes encoding the enzyme ZAP-70 would lead to which of the following?
Correct Answer: C
Rationale: ZAP-70 mutations impair T cell signaling, leading to SCID due to defective T cell development.
Question 2 of 5
The spleen has a red pulp (macrophages and red blood cells) and a white pulp (dense lymphoid tissue). T cells are found chiefly in the and B cells are found in the both within the pulp.
Correct Answer: A
Rationale: T cells are in PALS, B cells in follicles, both in white pulp.
Question 3 of 5
lymphocytes migrate to and lodge in selected tissue sites (lymphocyte homing). constantly circulate among the lymphoid organs until they encounter antigen or die.
Correct Answer: B
Rationale: Memory T cells home to tissues; naïve T cells circulate through secondary lymphoid organs.
Question 4 of 5
During B cell development, at what stage is membrane bound IgM found?
Correct Answer: D
Rationale: Membrane-bound IgM is expressed on immature B cells.
Question 5 of 5
Where does affinity maturation occur?
Correct Answer: B
Rationale: Affinity maturation occurs in germinal centers during the immune response.