ATI RN
Test Bank Pharmacology Questions
Question 1 of 9
Protamine Sulfate is known to counteract the therapeutic effect of which medication?
Correct Answer: B
Rationale: Protamine sulfate is commonly used as an antidote for heparin overdose. Heparin is an anticoagulant medication given to prevent blood clots, but in cases of excessive bleeding or overdose, protamine sulfate can be administered to counteract its effects. Therefore, it is important to be aware that protamine sulfate can negate the therapeutic effect of heparin.
Question 2 of 9
Drugs which antagonizes the anticoagulant effects of heparin
Correct Answer: C
Rationale: Protamine sulfate is a medication that can antagonize the anticoagulant effects of heparin. Heparin works by binding to antithrombin III to enhance its activity, which leads to the inhibition of factor Xa and thrombin. Protamine sulfate, a positively charged molecule, binds to heparin to form a stable complex, neutralizing the anticoagulant effects of heparin. This makes protamine sulfate a useful antidote for heparin overdose or in situations where rapid reversal of heparin is necessary to reduce the risk of bleeding complications. The other options listed - acetylcysteine, naloxone, warfarin sodium, and phenindione - do not have a direct antagonistic effect on the anticoagulant effects of heparin.
Question 3 of 9
A 25-year-old woman suffers a bee sting and within a few minutes she notices a blotchy rash appearing on her body. She is taken to A&E where her BP is 90/60 mmHg. The most appropriate immediate therapy would be:
Correct Answer: D
Rationale: Anaphylaxis (rash, hypotension) post-bee sting needs urgent reversal. Oral antihistamine is too slow for systemic shock. IV adrenaline (1:10000) suits cardiac arrest, not initial anaphylaxis. IV hydrocortisone acts slowly, supporting later. IM adrenaline (0.5 mL 1:1000, 0.5 mg) rapidly reverses bronchospasm and hypotension via alpha/beta agonism, the immediate therapy per guidelines. Salbutamol targets asthma, not shock. IM adrenaline's speed saves lives in anaphylaxis.
Question 4 of 9
Which of the following is the antidote for Heparin?
Correct Answer: A
Rationale: Protamine sulfate is the antidote for Heparin. Heparin is an anticoagulant medication that works by inhibiting the clotting factors in the blood. In cases of Heparin overdose or when there is a need to reverse its anticoagulant effects quickly, protamine sulfate can be administered. Protamine sulfate binds to Heparin and neutralizes its anticoagulant effects, making it an effective antidote. It is important to administer the antidote under the guidance of a healthcare professional to prevent any adverse reactions.
Question 5 of 9
A 22-year-old man with seasonal allergic rhinitis takes an antihistamine for relief of symptoms. It is successful for him over 90% of the time. Histamine is a natural amine formed by the decarboxylation of which of the following amino acids?
Correct Answer: C
Rationale: Histamine, key in allergies, is derived from histidine via decarboxylation. L-arginine , Lysine , and Tyrosine (E) form other amines. Heparin is a glycosaminoglycan. Histidine's conversion drives allergic responses, blocked by antihistamines.
Question 6 of 9
A patient about to receive a morning dose of digoxin has an apical pulse of 53 beats/min. What will the nurse do next?
Correct Answer: D
Rationale: The correct action is to check the radial pulse for 1 full minute. When administering digoxin, it is important to assess the apical pulse before giving the medication. A heart rate of 53 beats/min is below the normal range, especially for a patient taking digoxin, which can slow heart rate further. The nurse should check the radial pulse for a full minute to verify the heart rate accurately and assess for any abnormalities. This step is crucial to ensure patient safety and prevent potential complications associated with bradycardia. In this situation, it is necessary to withhold the dose and notify the prescriber to determine the appropriate course of action based on the assessment findings.
Question 7 of 9
The nurse will administer medication to a school-age child. What is the preferred action by the nurse?
Correct Answer: A
Rationale: School-age kids (6-12) can understand drug purpose and side effects-e.g., 'This fights infection, you might feel sleepy'-fostering cooperation via cognitive growth. Threats like no recess breed resentment, not trust. Beverage choice helps but lacks education. Play delays, not enhances, administration. Teaching leverages development, improving adherence.
Question 8 of 9
A patient has a digoxin level of 1.1 ng/mL. Which interpretation by the nurse is correct?
Correct Answer: A
Rationale: The therapeutic range for digoxin levels is typically between 0.8-2.0 ng/mL. A digoxin level of 1.1 ng/mL falls below the lower end of the therapeutic range, indicating that it is below the level considered effective for therapeutic benefits. Therefore, the correct interpretation by the nurse is that it is below the therapeutic level.
Question 9 of 9
The nurse teaches a patient taking amphotericin B to report which signs and symptoms to the health care provider?
Correct Answer: C
Rationale: Amphotericin B is an antifungal medication that can cause nephrotoxicity, leading to decreased urine output and renal impairment. Patients should be instructed to report any changes in urinary output promptly. Changes in sight and hearing are not typical adverse effects of amphotericin B. A painful red rash and blisters may indicate an allergic reaction but are less common than nephrotoxicity.