Piperazine antagonizes the anthelmintic action of the following drug

Correct Answer: A

Rationale: Piperazine and pyrantel pamoate have opposing effects on nematode muscle (relaxation vs. contraction), antagonizing each other.

Correct Answer: B

Rationale: Griseofulvin is specifically used for dermatomycosis (superficial fungal infections of skin, hair, and nails) by inhibiting fungal mitosis, unlike the others which target different fungi or bacteria.

Correct Answer: D

Rationale: Amphotericin B binds to ergosterol in fungal cell membranes, forming pores that alter permeability and cause cell leakage, leading to fungal death.

Correct Answer: B

Rationale: Amphotericin B is nephrotoxic (causing renal impairment) and can cause anemia due to bone marrow suppression, unlike the other listed effects which are less common.

Correct Answer: B

Rationale: Rifampin binds to DNA-dependent RNA polymerase in bacteria, inhibiting RNA synthesis, a critical step in TB treatment.