ATI RN
Pediatric Immunization Test Questions Questions
Question 1 of 5
Pepsin cleaves what region of immunoglobulin?
Correct Answer: C
Rationale: Pepsin cleaves below the hinge region, producing F(ab')2 fragments.
Question 2 of 5
During the development of B cells, the Ig gene segments are rearranged and brought next to each other to form a contiguous functional gene (somatic recombination). The complex of enzymes involved in somatic recombination in lymphocytes is called:
Correct Answer: C
Rationale: V(D)J-recombinase, including RAG-1 and RAG-2, facilitates somatic recombination in B and T cells.
Question 3 of 5
In heterozygous individuals who have, for example, inherited two alternative forms of the constant region gene for IgG1 (i.e., IgG1m(1) and IgG1m(2)), which of the following is true regarding the Ig expression by a particular B cell, according to allelic exclusion?
Correct Answer: D
Rationale: Allelic exclusion ensures that a B cell expresses only one allele, either IgG1m(1) or IgG1m(2).
Question 4 of 5
The process used to increase antigen binding affinity is called somatic and occurs in cells but not cells.
Correct Answer: C
Rationale: Somatic hypermutation increases affinity in B cells but not in T cells.
Question 5 of 5
Co-receptor molecule involved in signal transduction
Correct Answer: C
Rationale: CD4 and CD8 are co-receptors that enhance signal transduction in T cells.