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Drugs Affecting the Female Reproductive System NCLEX Quizlet Questions
Question 1 of 5
Parenteral testosterone therapy in a boy can cause the following adverse effects except:
Correct Answer: D
Rationale: The correct answer is D: Precocious puberty. Parenteral testosterone therapy can suppress endogenous testosterone production, delaying puberty rather than causing precocious puberty. Gynaecomastia (A), acne (B), and cholestatic jaundice (C) are possible adverse effects of testosterone therapy due to its impact on hormone levels and liver function. However, precocious puberty is not a known side effect of testosterone therapy in boys.
Question 2 of 5
Circulating testosterone levels in men are elevated during treatment with:
Correct Answer: A
Rationale: The correct answer is A: Danazol. Danazol is a synthetic androgen that suppresses gonadotropin secretion, leading to elevated testosterone levels. Finasteride inhibits 5-alpha-reductase, reducing dihydrotestosterone levels. Flutamide is an androgen receptor antagonist, lowering testosterone levels. Ketoconazole inhibits steroid synthesis, decreasing testosterone production. Therefore, only Danazol directly increases circulating testosterone levels in men.
Question 3 of 5
Estrogen therapy in postmenopausal women has been implicated in increasing the risk of the following disorders except:
Correct Answer: B
Rationale: Estrogen therapy in postmenopausal women decreases the risk of osteoporosis by preserving bone density. Estrogen deficiency after menopause is a major risk factor for osteoporosis. The increased risk of gall stones, endometrial carcinoma, and breast cancer are associated with estrogen therapy due to its effects on bile composition, endometrial cell proliferation, and breast tissue growth, respectively. Therefore, the correct answer is B as estrogen therapy actually helps prevent osteoporosis in postmenopausal women.
Question 4 of 5
Estrogen therapy can worsen the following associated conditions except:
Correct Answer: B
Rationale: Estrogen therapy can worsen conditions that are sensitive to hormonal fluctuations. Cholelithiasis (gallstones) is not influenced by estrogen levels, so it is not worsened by estrogen therapy. Migraine, acne vulgaris, and endometriosis are conditions known to be affected by estrogen levels and can potentially worsen with estrogen therapy. Therefore, the correct answer is B. Migraine can worsen due to estrogen's impact on blood vessels, acne vulgaris can worsen due to increased sebum production, and endometriosis can worsen due to estrogen's role in promoting tissue growth.
Question 5 of 5
Select the compound which used for hormone replacement therapy in postmenopausal women serves the purpose of both estrogen and progestin with weak androgenic activity:
Correct Answer: A
Rationale: Rationale: 1. Tibolone is a compound used for hormone replacement therapy in postmenopausal women. 2. Tibolone serves the purpose of both estrogen and progestin. 3. It has weak androgenic activity, making it suitable for menopausal symptoms. 4. Mestranol is an estrogen-only compound, not suitable for progestin effects. 5. Desogestrel and Gestodene are progestins but do not have estrogenic properties. In summary, Tibolone is the correct choice as it combines estrogen and progestin with weak androgenic activity, unlike the other options.