ATI RN
NCLEX Pediatric Immunization Questions Questions
Question 1 of 5
Papain cleaves what region of immunoglobulin?
Correct Answer: C
Rationale: Papain cleaves above the hinge region, yielding two Fab fragments and one Fc.
Question 2 of 5
In somatic recombination, the rearranges first. The region of the antibody molecule is generated via somatic recombination as it binds to the antigen and contains both a constant region and a variable region.
Correct Answer: A
Rationale: The heavy chain rearranges first, and the Fab region, which binds antigen, is generated via somatic recombination.
Question 3 of 5
Protein and nucleic acid sequence data have been obtained for many TCRs with different specificities. Analyses of these sequences suggest the existence of how many hypervariable (hv) regions within the variable region?
Correct Answer: C
Rationale: TCRs have three hypervariable regions (CDR1, CDR2, CDR3) within their variable regions, similar to immunoglobulins.
Question 4 of 5
Deficiencies in lead to autosomal-recessive severe combined immunodeficiency disease (SCID).
Correct Answer: C
Rationale: Deficiencies in either RAG-1 or RAG-2 can cause SCID due to impaired V(D)J recombination.
Question 5 of 5
Adhesion molecule
Correct Answer: D
Rationale: CD11a (LFA-1) is an adhesion molecule that stabilizes T cell interactions.