ATI RN
Chemotherapy drugs Questions
Question 1 of 5
One chemotherapeutic strategy used to eradicate the blood-stream form of African trypanosomes is based on the absolute dependence of the organism on
Correct Answer: C
Rationale: African trypanosomes rely heavily on glycolysis for energy, making drugs that target this pathway effective.
Question 2 of 5
This drug is the antimalarial agent most commonly associated with causing an acute hemolytic reaction in patients with glucose - 6 - phosphate dehydrogenase deficiency.
Correct Answer: D
Rationale: Primaquine causes hemolysis in G6PD-deficient patients due to oxidative stress on red blood cells.
Question 3 of 5
A missionary from Chicago is sent to work in a geographic region of a Cental American country wher onchocerca volvulus is endemic. Infections due to this tissue nematode (onchocerciasis) are a major cause of 'river blindness', since microfilariae migrate through subcutaneous tissues and concentrate in the eyes. Which one of the following durgs can be used prophylactically to prevent onchocerciasis?
Correct Answer: B
Rationale: Ivermectin is used prophylactically and therapeutically for onchocerciasis by killing microfilariae, preventing 'river blindness'.
Question 4 of 5
Which of the following agents used in drug combination regimens to treat testicular carcinoma is mot likely to cause nephrotoxicity?
Correct Answer: B
Rationale: Cisplatin is notorious for causing nephrotoxicity, a common side effect in testicular carcinoma treatment regimens.
Question 5 of 5
Which cell involved in immune function recognizes foreign peptides bound of MHC class II molecules on the surface of APC cells, secretes interleukin-2, and initiates the cell-mediated immunity reaction responsible for host-versus-graft reactions?
Correct Answer: D
Rationale: T-helper (TH) lymphocytes recognize MHC class II-bound peptides, secrete IL-2, and initiate cell-mediated immunity, including host-versus-graft reactions.