Non thrombocytopenic purpura is seen in all except:

Correct Answer: D

Rationale: The correct answer is D: SLE. Non-thrombocytopenic purpura is characterized by skin bleeding without low platelet count. SLE does not typically cause this type of purpura, as it primarily affects multiple organs through immune complex deposition. Vasculitis, uraemia, and hereditary hemorrhagic telangiectasia can all lead to non-thrombocytopenic purpura due to various mechanisms involving blood vessel inflammation, kidney dysfunction, or genetic defects in blood vessel formation, respectively.

Correct Answer: D

Rationale: The correct answer is D, hereditary spherocytosis. In this condition, the presence of jaundice and splenomegaly is due to the destruction of red blood cells by the spleen, leading to increased MCH. In liver cirrhosis (choice A), jaundice is due to impaired liver function. Thalassemia major (choice B) presents with severe anemia, not jaundice. Paroxysmal nocturnal hemoglobinuria (choice C) is characterized by hemolytic anemia and not typically associated with splenomegaly and jaundice. Therefore, the presence of jaundice, splenomegaly, and increased MCH points towards hereditary spherocytosis.

Correct Answer: B

Rationale: Step-by-step rationale for choice B (pancreatitis) being correct: 1. Sickle cell anemia primarily affects red blood cells, leading to vaso-occlusive crises. 2. Pancreatitis is not a known complication of sickle cell anemia. 3. Complications of sickle cell anemia commonly involve organs affected by sickling, such as the bones (osteomyelitis), kidneys (papillary necrosis), and heart (CHF). Summary: A: Papillary necrosis - Correct, as it can affect the kidneys in sickle cell anemia. B: Pancreatitis - Correct, as it is not a typical complication of sickle cell anemia. C: Osteomyelitis - Incorrect, as it can affect the bones in sickle cell anemia. D: CHF - Incorrect, as it can affect the heart in sickle cell anemia.

Correct Answer: D

Rationale: Macrocytosis is characterized by enlarged red blood cells. In Systemic Lupus Erythematosus (SLE), macrocytosis is not a typical finding. The other conditions listed - anemia of myxedema, methotrexate-induced macrocytosis, and macrocytosis due to chronic alcoholism-induced liver disease - are associated with macrocytosis due to various underlying mechanisms. Therefore, the correct answer is D, as macrocytosis is not a characteristic feature of SLE.

Correct Answer: A

Rationale: The correct answer is A: Hypercalcemia. In multiple myeloma, bone destruction releases calcium into the bloodstream, leading to hypercalcemia. Elevated serum viscosity (C) is not typically associated with multiple myeloma. Hyperproteinemia (B) may be present due to increased production of abnormal proteins, but it does not directly cause bone destruction. Elevated RBC count (D) is not a common finding in multiple myeloma and is not directly related to bone destruction.