ATI RN
Pediatric Immunity NCLEX Questions Questions
Question 1 of 5
Mutations in the gammac chain of the receptors for IL-2, 4, 7, 9 and 15 lead to?
Correct Answer: D
Rationale: Mutations in the common gamma chain (γc) disrupt signaling for multiple interleukins, causing severe combined immunodeficiency (SCID).
Question 2 of 5
The first immunoglobulin heavy chain class to be expressed on the surface of a newly produced B-cell is...?
Correct Answer: D
Rationale: IgM is the first immunoglobulin expressed on naive B cells, followed by co-expression with IgD during maturation.
Question 3 of 5
Long-term effective therapy for the patient described in Question 2 is best accomplished with
Correct Answer: B
Rationale: Interferon-γ is a standard long-term therapy for chronic granulomatous disease (CGD) as it enhances phagocyte function and reduces infection frequency. IVIG is used for antibody deficiencies, IL-2 for T-cell issues, and bone marrow transplantation for severe combined immunodeficiencies, not primarily for CGD.
Question 4 of 5
Matching: Immunodeficiency - Mandibular hypoplasia
Correct Answer: A
Rationale: DiGeorge syndrome includes facial anomalies like mandibular hypoplasia due to 22q11.2 deletion affecting branchial arch development.
Question 5 of 5
Which of the following tests is an effective screening for T-cell function?
Correct Answer: A
Rationale: Absolute lymphocyte count is a simple, effective screening test for T-cell function, as T cells constitute most lymphocytes. Low counts suggest T-cell deficiency.