MHC class I has three genes (HLA-A, HLA-B, & HLA-C). Which of the following is the correct order from most alleles (most polymorphic) to least alleles?

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Pediatric Immunization NCLEX Questions Quizlet Questions

Question 1 of 5

MHC class I has three genes (HLA-A, HLA-B, & HLA-C). Which of the following is the correct order from most alleles (most polymorphic) to least alleles?

Correct Answer: C

Rationale: HLA-B is the most polymorphic, followed by HLA-A, then HLA-C.

Question 2 of 5

Directly: carbohydrate, protein, lipid, nucleic acid epitopes

Correct Answer: A

Rationale: Immunoglobulins directly recognize a wide range of epitopes.

Question 3 of 5

Mutations in TAP-1 or TAP-2 may alter the function of the heterodimer TAP. Which of the following is common for patients with TAP mutations?

Correct Answer: C

Rationale: TAP mutations impair MHC Class I antigen presentation, leading to increased susceptibility to upper respiratory infections due to reduced CD8+ T cell responses.

Question 4 of 5

B cell co-receptor phosphorylation sites include Igα/Igβ and which of the following?

Correct Answer: A

Rationale: CD19 contains phosphorylation sites critical for amplifying BCR signaling.

Question 5 of 5

Important role in allergic response; heparin & histamine

Correct Answer: C

Rationale: Basophils release histamine and heparin in allergic responses.

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