Metabolic acidosis with increased anion gap occurs in

Questions 28

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Pediatric Musculoskeletal Questions

Question 1 of 5

Metabolic acidosis with increased anion gap occurs in

Correct Answer: D

Rationale: Severe anemia increases anion gap via lactic acidosis; others cause normal anion gap acidosis.

Question 2 of 5

In Duchenne muscular dystrophy (DMD), ambulation is important not only for postponing the psychologic depression but also for postponing

Correct Answer: B

Rationale: Prolonged ambulation in DMD helps delay scoliosis, a common complication due to weakened paraspinal muscles, which worsens after loss of mobility.

Question 3 of 5

Muscle denervation is any loss of nerve supply regardless of the cause. Of the following, the MOST specific clinical sign of denervation is

Correct Answer: D

Rationale: Fasciculation is the most specific sign of denervation, reflecting spontaneous motor unit activity due to nerve loss.

Question 4 of 5

Patients in early stages of Guillain-Barré syndrome should be admitted to the hospital for observation because the ascending paralysis can rapidly involve respiratory muscles during the next 24 hr. Of the following, the MOST effective treatment is

Correct Answer: D

Rationale: IVIG is one of the most effective treatments for GBS, alongside plasmapheresis, with strong evidence for hastening recovery.

Question 5 of 5

The Creatine kinase (CK) which is found in only 3 organs and may be separated into corresponding isozymes: MM for skeletal muscle, MB for cardiac muscle, and BB for brain. Of the following, the CK level is characteristically elevated in

Correct Answer: D

Rationale: CK is characteristically elevated in Duchenne muscular dystrophy due to extensive muscle breakdown.

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