ATI RN
Pediatric Immunization Practice Questions Questions
Question 1 of 5
Matching: Immunodeficiency - Most severe of congenital immunodeficiencies
Correct Answer: B
Rationale: SCID is the most severe congenital immunodeficiency, with absent T and B cell function, leading to early, life-threatening infections.
Question 2 of 5
Which of the following is not associated with neutropenia?
Correct Answer: A
Rationale: Leukocyte adhesion deficiency (LAD) causes leukocytosis, not neutropenia, due to impaired neutrophil migration, unlike the other conditions.
Question 3 of 5
A 13-month-old male presented with vomiting, fever, and irritability. On examination his temperature was 40°C, lethargic, with atrophied tonsils, clear tympanic membrane, clear chest and neck stiffness. The parents gave past history of pneumonia at the age of 6 and 9 months for which he was admitted to hospital and treated with i.v. antibiotics for 10 days. Of the following, the MOST likely diagnosis is
Correct Answer: A
Rationale: Recurrent bacterial infections and absent tonsils suggest agammaglobulinemia, likely X-linked, due to severe B-cell deficiency.
Question 4 of 5
An 18-month-old male child presented with failure to thrive and chronic diarrhea. On examination he has dermatitis, generalized lymphadenopathy, hepatosplenomegaly, and deep seated infection in the inguinal area. His lab. investigations revealed anemia and hypergammaglobulinemia. Of the following, the MOST likely diagnosis is
Correct Answer: D
Rationale: Chronic granulomatous disease causes failure to thrive, deep infections, and hypergammaglobulinemia due to defective phagocyte killing.
Question 5 of 5
Which of the following regulators inhibits C3convertase
Correct Answer: D
Rationale: CD46 (membrane cofactor protein) inhibits C3 convertase by promoting its degradation, regulating the complement system to prevent excessive activation.