Main complications of insulin therapy include the following:

Correct Answer: D

Rationale: The correct answer is D, "All of the above." Insulin therapy can lead to hypoglycemia due to excessive insulin dosage, insulin allergy in some rare cases, and lipodystrophy at injection sites from repeated injections. Each complication is a potential risk of insulin therapy, making all choices relevant. Therefore, option D is the correct answer as it encompasses all possible complications. Choices A, B, and C individually address specific complications but do not cover the full scope of potential issues associated with insulin therapy, making them incorrect in this context.

Correct Answer: C

Rationale: The correct answer is C: Inhibits calcineurin. Sirolimus inhibits the mTOR pathway by binding to FKBP12 and forming a complex that inhibits the activity of mTOR complex 1. Calcineurin is not directly involved in the mechanism of action of sirolimus. Choice A is incorrect because sirolimus does not involve anti-idiotype antibodies. Choice B is incorrect because sirolimus does not modulate the CD3 receptor. Choice D is incorrect because sirolimus does not mediate ADCC towards T lymphocytes.

Correct Answer: B

Rationale: Step 1: Identify the statement - "Vitamin K enhances the anticoagulant property of coumarins." Step 2: Recall that Vitamin K is actually involved in blood clotting, counteracting anticoagulants. Step 3: Understand that coumarins are anticoagulants that work by inhibiting Vitamin K. Step 4: Therefore, the statement is FALSE as Vitamin K doesn't enhance but counteracts coumarins. Summary: Choice A is incorrect because the statement is false, Choice C and D are incorrect as they do not apply to the given scenario.

Correct Answer: A

Rationale: The correct answer is A because nicotinic acid (niacin) increases the rate of catabolism of VLDL by inhibiting lipolysis in adipose tissue, leading to decreased free fatty acids available for VLDL synthesis. This results in decreased VLDL production and increased clearance, thus lowering plasma VLDL levels. Option B is incorrect because nicotinic acid does not decrease VLDL catabolism. Option C is incorrect as not all choices are correct. Option D is incorrect as there is a correct answer.

Correct Answer: A

Rationale: Rationale: A: Correct. Calcitriol regulates calcium and phosphate levels, leading to potential ectopic calcification. Monitoring is crucial. B: Incorrect. Calcitriol does undergo enterohepatic circulation. C: Incorrect. Calcitriol is not toxic to osteoclasts; it has a role in bone health. D: Incorrect. Calcitriol has a complex relationship with bioavailability, affected by several factors.