ATI RN
Cardiovascular Drugs Pharmacology PPT Questions
Question 1 of 5
Main agents for acute migraine attack treatment are Ergot and indol derivatives and NSAID’s. The consideration is:
Correct Answer: A
Rationale: The correct answer is A: TRUE. Ergot and indol derivatives, along with NSAIDs, are indeed main agents for acute migraine attack treatment. Ergot derivatives like ergotamine and dihydroergotamine are vasoconstrictors that help alleviate migraine symptoms by reducing blood flow in the brain. Indol derivatives like sumatriptan are serotonin receptor agonists that also help relieve migraines. NSAIDs like ibuprofen can help reduce inflammation and pain associated with migraines. Therefore, the statement is true. Summary of other choices: B: FALSE - This choice is incorrect as the statement in the question is true. C: Null - This choice is incorrect as it does not provide any relevant information to the question. D: All - This choice is incorrect as it implies that all agents are main agents for acute migraine attack treatment, which is not accurate.
Question 2 of 5
Anti-inflammatory effect of glucocorticoids is caused by
Correct Answer: D
Rationale: The correct answer is D because glucocorticoids have a multi-faceted anti-inflammatory effect. 1. Glucocorticoids inhibit phospholipase A2, reducing prostaglandins and leukotrienes, which are pro-inflammatory mediators. 2. They also decrease macrophage migration to the site of inflammation, reducing inflammation. 3. Glucocorticoids decrease capillary permeability, which helps in reducing swelling and edema. Therefore, all of the above mechanisms contribute to the anti-inflammatory effect of glucocorticoids. Other choices are incorrect because they do not encompass all the key mechanisms involved in the anti-inflammatory effects of glucocorticoids.
Question 3 of 5
Indications for administration of histamine H1 antagonists are the following EXCEPT:
Correct Answer: B
Rationale: Step 1: Histamine H1 antagonists are commonly used to treat allergic reactions by blocking histamine release. Step 2: Nausea and vomiting in pregnancy can be treated with H1 antagonists like doxylamine. Step 3: Sleep disorders are not typically treated with H1 antagonists, but rather with medications targeting other pathways. Step 4: Seizure states are not a common indication for H1 antagonists and have no direct relation to histamine pathways. Step 5: Therefore, choice B is the correct answer as it does not align with the typical indications for histamine H1 antagonists.
Question 4 of 5
Which of the following statements concerning vitamin B1 functions are true:
Correct Answer: B
Rationale: The correct answer is B because vitamin B1, also known as thiamine, is indeed an essential coenzyme for the oxidative decarboxylation of alpha-keto acids, including the conversion of pyruvate to acetyl coenzyme A in the citric acid cycle. This process is crucial for energy production in the form of ATP. Choice A is incorrect because vitamin B1 is not primarily an antioxidant but rather a coenzyme involved in energy metabolism. Choice C is incorrect because vitamin B1 is not required for the synthesis of prothrombin or clotting factors. Choice D is incorrect because flavoproteins, FMN, and FAD are associated with vitamin B2 (riboflavin), not vitamin B1.
Question 5 of 5
Women taking probucol (Lorelco) should wait for 6 months after cessation of therapy before becoming pregnant. This consideration is:
Correct Answer: A
Rationale: The correct answer is A: TRUE. Probufol can stay in the body for a long time, and waiting 6 months after stopping the medication before becoming pregnant is crucial to prevent potential harm to the fetus. This waiting period allows the drug to be eliminated from the body, reducing the risk of any adverse effects on the pregnancy. Choice B (FALSE) is incorrect because it is important for women to wait before becoming pregnant after stopping probucol therapy. Choices C (All) and D (None) are also incorrect as they do not accurately represent the specific guideline related to probucol use and pregnancy.