Loss of tumor suppression in a cell usually results from:

Questions 45

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Pediatrics Genetics Questions

Question 1 of 5

Loss of tumor suppression in a cell usually results from:

Correct Answer: D

Rationale: Loss of tumor suppressor function often occurs via deletion or mutation, removing its inhibitory effect.

Question 2 of 5

Although BRAC2 was initially found associated with breast cancer, it also increases the risk for cancers in the

Correct Answer: B

Rationale: BRCA2 (likely meant) increases risk for pancreatic cancer, among others, in addition to breast and ovarian cancer.

Question 3 of 5

Cancer cells probably arise frequently but are detected and eliminated by our immune system:

Correct Answer: A

Rationale: True. Immune surveillance eliminates many nascent cancer cells (immunoediting hypothesis).

Question 4 of 5

An extra finger in humans is rare but is due to a dominant gene. When one parent is normal and the other parent has an extra finger but is heterozygous for the trait, what is the probability that the first child will be normal?

Correct Answer: C

Rationale: Heterozygous (Aa) x normal (aa) gives 50% Aa (extra finger) and 50% aa (normal).

Question 5 of 5

Which of the following would result in Angelman syndrome?

Correct Answer: A

Rationale: Angelman syndrome results from loss of maternal 15q11-13 (e.g., maternal UPD or paternal deletion).

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