ATI RN
Common Pediatric Genetic Disorders Questions
Question 1 of 5
Leber’s hereditary optic atrophy is caused by a mutation in:
Correct Answer: D
Rationale: Leber’s hereditary optic neuropathy (LHON) is caused by mitochondrial DNA mutations, inherited maternally.
Question 2 of 5
The childhood kidney cancer Wilms’ tumor is caused by:
Correct Answer: C
Rationale: Wilms’ tumor is associated with loss of the WT1 tumor suppressor gene on chromosome 11p13.
Question 3 of 5
Which statement is true?
Correct Answer: C
Rationale: Most cancers are sporadic, resulting from multiple somatic mutations over time.
Question 4 of 5
DNA microarrays and human genome data are being used to diagnose and manage cancer:
Correct Answer: A
Rationale: True. Microarrays and genomic data help identify cancer mutations and guide treatment.
Question 5 of 5
cells are commonly used today in research laboratories. They are from a cervical cancer patient who died in 1951:
Correct Answer: A
Rationale: HeLa cells, from Henrietta Lacks’ cervical cancer, are widely used in research.