ATI RN
Pediatric Immunization NCLEX Questions Ricci Questions
Question 1 of 5
Killed vaccines are theoretically much safer than live vaccines, but cannot replicate in hosts and cannot enter intracellular antigen presenting pathways. Which of the following killed vaccines is recommended for children but not adults?
Correct Answer: C
Rationale: Inactivated poliovirus vaccine (IPV) is standard for children, while adults typically rely on prior immunity or boosters.
Question 2 of 5
An infant presents with recurrent infections with Candida and viruses. Cardiac abnormalities result in the patient requiring heart surgery. During surgery, no thymus is found. Which of the following is the most likely?
Correct Answer: A
Rationale: DiGeorge's syndrome features thymic aplasia, cardiac defects, and recurrent infections due to T cell deficiency.
Question 3 of 5
Activation of macrophages is best achieved by which cytokine?
Correct Answer: A
Rationale: Interferon gamma (IFN-γ) is the primary cytokine for activating macrophages, enhancing their phagocytic and microbicidal activity.
Question 4 of 5
Deletions in the T-cell CD154 (CD40L) gene produce?
Correct Answer: A
Rationale: CD40L deficiency prevents class switching from IgM to other isotypes, resulting in hyper-IgM syndrome.
Question 5 of 5
Which of the following vaccines should not be administered to severely immunocompromised patients...?
Correct Answer: C
Rationale: The MMR vaccine is live attenuated and contraindicated in severely immunocompromised patients due to the risk of vaccine-derived infection.