ATI RN
Proctored Pharmacology ATI Questions
Question 1 of 5
Individuals who are slow acetylators (i.e. have a relatively low activity of hepatic N-acetyltransferase):
Correct Answer: D
Rationale: Slow acetylators have reduced hepatic N-acetyltransferase (NAT2) activity, affecting metabolism of drugs like hydralazine, isoniazid, and procainamide. In European Caucasians, prevalence is actually 50-60%, not 15-20%, making that statement inaccurate. Gold treatment side effects like thrombocytopenia or nephrotic syndrome aren't strongly linked to acetylation status, but rather to immune responses, so that's less relevant. Halothane hepatotoxicity relates to immune-mediated reactions or metabolites, not acetylation speed. Hydralazine, metabolized by NAT2, accumulates in slow acetylators, increasing risk of drug-induced lupus with antinuclear antibodies (ANA), a well-documented association. Agranulocytosis with clozapine isn't tied to acetylation but to idiosyncratic reactions. The ANA risk with hydralazine is the most accurate, reflecting its pharmacogenetic implications, critical for personalized dosing and monitoring.
Question 2 of 5
The nursing instructor teaches student nurses about male reproductive function and the role of follicle-stimulating hormone (FSH). The instructor evaluates learning has occurred when the students make which statement?
Correct Answer: A
Rationale: Follicle-stimulating hormone (FSH), secreted by the pituitary gland, targets Sertoli cells in the testes to stimulate spermatogenesis, the process of sperm production, making it a key regulator of male fertility. Androgen production, primarily testosterone, is governed by luteinizing hormone (LH), not FSH, though both hormones collaborate in reproductive function. Testosterone synthesis occurs in Leydig cells under LH's influence, not FSH, which focuses on supporting sperm maturation rather than hormone production. Progesterone, while present in trace amounts in males, isn't regulated by FSH, as it's more relevant to female reproductive cycles. The specificity of FSH's role in spermatogenesis distinguishes it from broader hormonal regulation, ensuring students grasp its targeted action in the seminiferous tubules, critical for understanding male reproductive physiology and distinguishing it from LH's testosterone-driven effects.
Question 3 of 5
While discussing antihypertensives, the instructor states that a particular agent causes a reduction in blood pressure by blocking receptor sites. The student wishing to understand this statement would research which drug information?
Correct Answer: D
Rationale: Blocking receptor sites to lower blood pressure describes the drug's mechanism of action-how it works (e.g., beta-blockers on adrenergic receptors). Interactions detail combined effects. Adverse effects list risks. Indication states purpose (hypertension). Mechanism explains the receptor-blocking process, key to understanding the statement, aligning with pharmacology's focus on action.
Question 4 of 5
The toddler refuses to take his oral medication. What is the best suggestion to the mother from the nurse for ensuring the toddler receives his medication?
Correct Answer: B
Rationale: Toddlers (1-3) resist meds-crushing a tablet (if safe) and mixing with jam masks taste, easing intake, per developmental needs. Bribery with toys may not work long-term. Milk risks interactions (e.g., tetracycline) or dilution. Punishment distresses, not helps. Jam leverages taste preference, ensuring delivery.
Question 5 of 5
Which drug type used to treat depression works by preventing enzymatic destruction of the neurotransmitter norepinephrine?
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.