Indicate the hypnotic drug which does not change hepatic drug-metabolizing enzyme activity?

Correct Answer: D

Rationale: The correct answer is D because all three drugs listed (Flurazepam, Zaleplon, Triazolam) do not significantly alter hepatic drug-metabolizing enzyme activity. These drugs primarily act on GABA receptors in the central nervous system, rather than affecting hepatic enzymes. Therefore, they do not interfere with the metabolism of other drugs in the liver. Choices A, B, and C are incorrect because all of them are hypnotic drugs that do not alter hepatic drug-metabolizing enzyme activity.

Correct Answer: C

Rationale: Rationale: 1. Bromocriptine is a D2 receptor agonist. 2. Stimulation of D2 receptors helps alleviate Parkinson's symptoms. 3. Sinemet and Levodopa are dopamine precursors but not D2 agonists. 4. Selegiline is a monoamine oxidase inhibitor, not a D2 agonist. In summary, Bromocriptine directly activates D2 receptors, making it the correct choice for antiparkinsonian activity.

Correct Answer: D

Rationale: Alcohol can cause CNS depression by slowing down brain function. It also leads to vasodilatation, widening blood vessels and lowering blood pressure. Additionally, alcohol can induce hypoglycemia by inhibiting glucose production in the liver. Therefore, all choices are correct, making option D the correct answer. Other choices are incorrect because they individually do not encompass all the effects of alcohol consumption.

Correct Answer: C

Rationale: The correct answer is C: Chlorpromazine. Chlorpromazine is a phenothiazine aliphatic derivative because it belongs to the phenothiazine class of antipsychotic drugs and has an aliphatic side chain. Thiothixene (A) is a thioxanthene derivative, not a phenothiazine. Risperidone (B) is an atypical antipsychotic, not a phenothiazine. Clozapine (D) is a dibenzodiazepine derivative, not a phenothiazine. Therefore, Chlorpromazine is the only option that fits the criteria of being a phenothiazine aliphatic derivative.

Correct Answer: A

Rationale: The correct answer is A: Protriptyline. This tricyclic agent has the least sedative effect due to its higher potency and faster metabolism compared to other options. Protriptyline has minimal sedative properties, making it a preferred choice for patients who cannot tolerate sedation. Trazodone (B), Amitriptyline (C), and Mirtazapine (D) are known to cause sedation due to their antihistaminic and alpha-adrenergic blocking effects.