ATI RN
Chemotherapy drugs Questions
Question 1 of 5
Indicate the condition in which neither trimethoprim nor sulfamethoxazole alone are effective, but their combination cotrimoxazole is
Correct Answer: C
Rationale: Cotrimoxazole is uniquely effective against Pneumocystis jirovecii pneumonia due to synergistic folate pathway inhibition.
Question 2 of 5
The intermittently multiplying (spurter) tubercle bacilli present within caseous material having low oxygen tension are most susceptible to
Correct Answer: B
Rationale: Rifampin is most effective against intermittently multiplying TB bacilli in low-oxygen environments like caseous lesions.
Question 3 of 5
Ethambutol is not used in children below 6 years of age because
Correct Answer: C
Rationale: Ethambutol’s visual toxicity (optic neuritis) is hard to detect in young children, who cannot reliably report symptoms.
Question 4 of 5
Addition of pyrazinamide and ethambutol for the first two months to the isoniazid + rifampin therapy of tuberculosis serves the following purpose(s)
Correct Answer: D
Rationale: Adding pyrazinamide and ethambutol shortens therapy to 6 months and speeds sputum conversion.
Question 5 of 5
Corticosteroids are absolutely contraindicated in which of the following types of tuberculosis
Correct Answer: B
Rationale: Corticosteroids are contraindicated in meningeal TB without anti-TB therapy, as they can worsen the infection; they may be used adjunctively in other types.