Indicate the antipsychotic drug having significant peripheral alpha-adrenergic blocking activity:

Correct Answer: B

Rationale: The correct answer is B: Chlorpromazine. Chlorpromazine has significant peripheral alpha-adrenergic blocking activity, leading to side effects like orthostatic hypotension. This is due to its antagonistic action on alpha-1 adrenergic receptors in the peripheral nervous system. Haloperidol (A) primarily acts on dopamine receptors in the brain. Clozapine (C) is known for its anticholinergic effects and does not have significant alpha-adrenergic blocking activity. Risperidone (D) primarily acts on dopamine and serotonin receptors, with minimal alpha-adrenergic blocking activity.

Correct Answer: D

Rationale: The correct answer is D: Prazepam. Prazepam is preferred for elderly patients due to its long half-life, which reduces the risk of accumulation and potential side effects. Clorazepate (A) and Clordiazepoxide (B) have active metabolites that may accumulate in the elderly. Triazolam (C) has a short half-life, leading to potential next-day sedation. Therefore, Prazepam is the safest choice for elderly patients.

Correct Answer: C

Rationale: Step-by-step rationale for why Ketamine (choice C) is the correct answer: 1. Ketamine is a known NMDA receptor antagonist, blocking the receptor's activity. 2. By inhibiting NMDA receptors, Ketamine produces dissociative anesthesia. 3. Thiopental (A) is a GABA agonist, Halothane (B) is a volatile anesthetic, and Sevoflurane (D) enhances GABA activity, not acting on NMDA receptors.

Correct Answer: A

Rationale: Step-by-step rationale: 1. Zafirlukast is a leukotriene receptor antagonist used to treat asthma. 2. Aspirin-sensitive asthma is a condition triggered by aspirin and other NSAIDs. 3. Studies have shown that zafirlukast can prevent bronchoconstriction in aspirin-sensitive asthma. 4. Therefore, the statement that Zafirlukast prevents aspirin-sensitive asthma is TRUE. Summary: - Choice A is correct because zafirlukast has been proven to prevent aspirin-sensitive asthma. - Choice B is incorrect as evidence supports the effectiveness of zafirlukast. - Choice C is incorrect as not all choices are true. - Choice D is incorrect as the correct answer is A, making this choice incorrect.

Correct Answer: B

Rationale: The correct answer is B: Prostacyclin (PGI2). Prostacyclin is synthesized within vessel walls and acts as a potent inhibitor of thrombogenesis by inhibiting platelet aggregation and promoting vasodilation. Thromboxane A2 (TXA2) (Choice A) is synthesized by platelets and promotes platelet aggregation. Prostaglandin E (PGE) (Choice C) is involved in various physiological processes but does not specifically inhibit thrombogenesis. Choice D is incorrect as Prostacyclin is indeed synthesized within vessel walls and inhibits thrombogenesis.