Increase Fe & normal TIBC are found in:

Correct Answer: C

Rationale: The correct answer is C: rheumatoid arthritis. In rheumatoid arthritis, there is chronic inflammation leading to elevated levels of ferritin (Fe) due to increased iron storage and a normal total iron-binding capacity (TIBC). This is because despite the increased iron stores, the body is unable to utilize it fully due to chronic inflammation. Incorrect choices: A: Thalassemia major would typically present with decreased TIBC due to increased iron absorption to compensate for the chronic anemia. B: Haemosiderosis would show elevated Fe but a decreased TIBC due to iron overload. D: Disseminated malignancy may show elevated Fe levels but typically with a decreased TIBC due to anemia of chronic disease.

Correct Answer: B

Rationale: Step 1: Cooley's anemia is another term for thalassemia major, a genetic disorder affecting hemoglobin production. Step 2: Thalassemia major results in severe anemia due to the body's inability to produce enough functional hemoglobin. Step 3: Sickle cell anemia (Choice A) is a different genetic disorder characterized by abnormal hemoglobin shape. Step 4: High ESR (Choice C) is a non-specific marker of inflammation, not specific to Cooley's anemia. Step 5: Aplastic anemia (Choice D) is a condition where the bone marrow does not produce enough blood cells, not specific to Cooley's anemia.

Correct Answer: C

Rationale: Step 1: Hepato-splenomegaly with lymphadenopathy is commonly seen in hematologic malignancies. Step 2: Chronic Myeloid Leukemia (CML) primarily presents with splenomegaly, but not lymphadenopathy. Step 3: Acute Lymphoblastic Leukemia (ALL), lymphoma, and disseminated TB can all present with these findings. Step 4: Therefore, the correct answer is C - CML, as it does not typically present with lymphadenopathy. Other choices are incorrect as they can present with these symptoms.

Correct Answer: B

Rationale: The correct answer is B (3-4 days) because the half-life of platinum is known to be around 3-4 days based on scientific research and studies. This means that within this time frame, half of the amount of platinum will decay or disintegrate. The other choices (A, C, D) are incorrect because they do not align with the established half-life value of platinum. Option A (1-2 days), C (5-6 days), and D (7-8 days) do not fall within the typical range of platinum's half-life duration as determined by scientific data and experimentation. Therefore, option B is the most accurate and scientifically supported choice for the half-life of platinum.

Correct Answer: A

Rationale: The correct answer is A: Monitoring for infection. In patients with acute leukemia, the most common cause of death is infection due to the suppression of the immune system by the disease and its treatment. By closely monitoring for signs of infection such as fever, chills, increased heart rate, and low white blood cell count, the nurse can promptly intervene and provide appropriate treatment to prevent complications and improve patient outcomes. The other choices are incorrect because while they are important aspects of care for patients with leukemia, monitoring for infection directly addresses the most critical risk factor leading to mortality in this patient population.