ATI RN
ATI Endocrine Pharmacology Quizlet Questions
Question 1 of 5
In the treatment of congenital adrenal hyperplasia in which there is excess production of cortisol precursors due to a lack of 21beta-hydroxylase activity, the purpose of administration of a synthetic glucocorticoid is
Correct Answer: D
Rationale: Synthetic glucocorticoids suppress ACTH, reducing adrenal stimulation and precursor accumulation in 21-hydroxylase deficiency.
Question 2 of 5
Hormones that form lipophilic esters without prior structural modifications include I. Hydrocortisone II. Testosterone III. Progesterone
Correct Answer: D
Rationale: All three (hydrocortisone, testosterone, progesterone) are lipophilic steroids forming esters.
Question 3 of 5
A 37-year-old kidney transplant recipient presents to her primary care physician for follow-up. Among other immunosuppressant drugs, she has been taking daily prednisone for the past 2 months since her transplant. With only a few doses of prednisone left, she gets snowed into her house and cannot refill her prescription (but she has enough of the other medications to last a few more weeks). If she runs out of prednisone and cannot get it refilled, what is she most at risk for developing?
Correct Answer: A
Rationale: Abrupt cessation of prednisone after prolonged use can lead to adrenal insufficiency due to suppression of the HPA axis, risking an adrenal crisis (cardiovascular collapse), which is life-threatening.
Question 4 of 5
A 33-year-old woman presents to her primary care physician with tachycardia, heat intolerance, tremor, and unintentional weight loss. A thyroid scan shows multiple regions of thyroid taking up excess iodine. She is prescribed with a drug that will decrease synthesis of thyroid hormones and decrease the peripheral conversion of \T_4 to \T_3. Which drug is this?
Correct Answer: D
Rationale: Propylthiouracil (PTU) inhibits thyroid hormone synthesis by blocking thyroid peroxidase and reduces peripheral \T_4 to \T_3 conversion, treating hyperthyroidism.
Question 5 of 5
A 27-year-old man was recently diagnosed with Type-2 diabetes mellitus and placed on a medication. As he was drinking with his friends, he became violently ill. What medication is he most likely taking?
Correct Answer: D
Rationale: Tolbutamide, a sulfonylurea, can cause a disulfiram-like reaction (violent illness) with alcohol due to inhibition of aldehyde dehydrogenase.