ATI RN
NCLEX Pediatric Immunization Questions Questions
Question 1 of 5
In the classical pathway, the antibody activated the C1 complex consisting of C1q, C1r & C1s subunit. Which of the following subunit binds to the antibody
Correct Answer: A
Rationale: C1q binds to the Fc region of antibodies, initiating the classical pathway.
Question 2 of 5
The viral infection in the above question began in the respiratory tract. Which antibody class would best protect respiratory epithelial cells from viral infection?
Correct Answer: A
Rationale: IgA is the primary antibody protecting mucosal surfaces like the respiratory tract.
Question 3 of 5
Dendritic cells, macrophages, and what other cell types are considered 'professional antigen presenting cells,' capable of antigen presentation to T helper cells?
Correct Answer: A
Rationale: B cells, dendritic cells, and macrophages are professional APCs expressing MHC II.
Question 4 of 5
A 5-year-old boy presents with his third episode of painful cervical lymphadenitis. Each was treated with incision and drainage and grew Staphylococcus aureus. At the age of 2 years, he required surgical aspiration of a liver abscess. The most important laboratory test is
Correct Answer: B
Rationale: The nitroblue tetrazolium (NBT) test assesses the ability of neutrophils to produce a respiratory burst, which is defective in chronic granulomatous disease (CGD). The history of recurrent Staphylococcus aureus infections and a liver abscess strongly suggests CGD, making the NBT test the most important diagnostic tool.
Question 5 of 5
Of the following, the findings that are MOST suggestive of DiGeorge syndrome are
Correct Answer: D
Rationale: Hypocalcemia (from parathyroid hypoplasia) and congenital heart defects are hallmark features of DiGeorge syndrome due to thymic and parathyroid underdevelopment.