ATI RN
Chapter 12 principles of pharmacology Questions
Question 1 of 5
In severe renal failure:
Correct Answer: D
Rationale: Smaller digoxin doses are required in severe renal failure (D), as its renal clearance (GFR <10 mL/min) drops, prolonging half-life, risking toxicity. Option A is false (pH may rise). Option B is incorrect (phenytoin range adjusts minimally). Option C lacks evidence. Option E (original) about omeprazole is false. Digoxin's renal dependence, critical in heart failure, necessitates adjustment, a key pharmacokinetic shift in renal impairment.
Question 2 of 5
Lipophilicity reduces
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 3 of 5
In which organ is the majority of cytochrome P450s most highly expressed?
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 4 of 5
Which of the following is a True statement?
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
MATCH the pharmacokinetic parameter or term to the appropriate statement. A main determinant of bioavailability (F) following oral administration
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.