ATI RN
ASCP Hematology Questions Questions
Question 1 of 5
In hereditary spherocytosis, all the following will resolve postsplenectomy EXCEPT
Correct Answer: A
Rationale: Splenectomy resolves anemia (B), reticulocytosis (C), hyperbilirubinemia (D), and aplastic crises (E) in HS by removing the site of RBC destruction. Osmotic fragility (A) persists, as it’s an intrinsic RBC defect.
Question 2 of 5
A healthy 5-mo-old boy appears pale. Examination is unremarkable. Lab findings include: Hb 8.1 g/dl; WBC 4,800/mm3; platelets 144,000/mm3; MCV, 111 fl; blood film showed hypersegmented neutrophils; serum B12, 65 pg/mL (low). The infant is vigorously breast fed. Of the following, the NEXT step of the management is
Correct Answer: B
Rationale: Low B12, macrocytic anemia, and hypersegmented neutrophils in a breastfed infant suggest maternal B12 deficiency. Checking maternal B12 (B) guides management, preceding treatment (C, D), transfusion (E), or Schilling test (A, less relevant in infants).
Question 3 of 5
All the following are correct regarding treatment of cold agglutinin disease EXCEPT
Correct Answer: D
Rationale: Cold agglutinin disease management includes avoiding cold (A), treating underlying causes (B), plasmapheresis (C), and rarely splenectomy (E). Glucocorticoids (D) are ineffective due to intravascular hemolysis.
Question 4 of 5
Transfusion of fresh frozen plasma (FFP) is efficacious for the treatment of deficiency of all the following coagulation factors EXCEPT
Correct Answer: D
Rationale: FFP provides factors V (A), X (B), XI (C), and protein C (E), but factor XIII (D) has low levels in FFP, requiring cryoprecipitate or concentrates for deficiency.
Question 5 of 5
In hemophilia A, factor VIII level activity should be increased to $100 \%$ in
Correct Answer: B
Rationale: Iliopsoas bleeding (B) in hemophilia A is life-threatening, requiring 100% factor VIII correction. Epistaxis (A), extraction (C), hematuria (D), and gum bleeding (E) need lower levels (30-50%).