ATI RN
ASCP Hematology Questions Questions
Question 1 of 5
In hemophilia A, factor VIII level activity should be increased to $100 \%$ in
Correct Answer: B
Rationale: Iliopsoas bleeding (B) in hemophilia A is life-threatening, requiring 100% factor VIII correction. Epistaxis (A), extraction (C), hematuria (D), and gum bleeding (E) need lower levels (30-50%).
Question 2 of 5
Which of the following is FALSE about factor V Leiden mutation?
Correct Answer: C
Rationale: Factor V Leiden is common (A), worse in homozygotes (B), increases venous thrombosis with OCPs (D), and causes abortions (E). Arterial thrombosis (C) is not significantly increased, making it false.
Question 3 of 5
A healthy 5-day-old male neonate develops bruising and melena. The pregnancy, and delivery course were unremarkable. The mother received heparin therapy for recurrent abortions secondary to lupus anticoagulants. The infant is vigorously breastfeeding. Examination reveals only multiple bruises. Lab tests reveals: hemoglobin, 8.4 g/dL; WBC, 8600/mm3; platelets count, 200000/mm3; PTT, 74 seconds; PT, 28 seconds; serum fibrinogen is normal. Of the following, the MOST likely cause of this bleeding is
Correct Answer: C
Rationale: Neonatal bruising, melena, and prolonged PT/PTT with normal platelets and fibrinogen suggest vitamin K deficiency (C), common in newborns without prophylaxis. DIC (A) lowers fibrinogen, hemophilia (B) is sex-linked, heparin (D) isn’t transferred via breast milk, and lupus anticoagulants (E) don’t cause bleeding.
Question 4 of 5
Which of the following is least likely to be associated with prolonged thrombocytopenia in children?
Correct Answer: A
Rationale: Acute ITP (A) typically resolves within months, unlike chronic conditions SLE (B), HIV (C), type 2B vWD (D), and WAS (E), which cause prolonged thrombocytopenia.
Question 5 of 5
A 9-month-old boy appears pale. Examination reveals a palpable liver $3 \mathrm{~cm}$ below the right costal margin and palpable spleen $4 \mathrm{~cm}$ below the left costal margin. Lab findings include: hemoglobin concentration, 6.4 g/dl; mean corpuscular volume (MCV), 67 fL; and WBC, 15,000/mm3. Of the following, The MOST valuable test to confirm the diagnosis is
Correct Answer: C
Rationale: Microcytic anemia (MCV 67 fL), hepatosplenomegaly, and severe anemia at 9 months suggest thalassemia major. Hemoglobin electrophoresis (C) confirms elevated Hb F and absent Hb A, more specific than smear (A), iron studies (B), marrow (D), or US (E).