In contrast to benzodiazepines,buspirone:

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Clinical Pharmacology of Cardiovascular Drugs PPT Questions

Question 1 of 5

In contrast to benzodiazepines,buspirone:

Correct Answer: C

Rationale: Rationale for correct answer (C): 1. Buspirone is a serotonin receptor agonist and does not directly interact with the GABAergic system. 2. Buspirone is not associated with marked hypnotic, anticonvulsant, or muscle relaxant properties. 3. Studies show that buspirone causes less psychomotor impairment and does not affect driving skills. 4. Therefore, choice C is correct as it accurately contrasts buspirone from benzodiazepines. Summary of incorrect choices: A. Benzodiazepines interact with the GABAergic system, not buspirone. B. Benzodiazepines have hypnotic, anticonvulsant, and muscle relaxant properties, not buspirone. D. Buspirone has minimal abuse liability compared to benzodiazepines, which have high abuse potential.

Question 2 of 5

Cimetidine has no effect on hepatic drug metabolism. It’s

Correct Answer: B

Rationale: The correct answer is B: FALSE. Cimetidine is a known inhibitor of hepatic drug metabolism, specifically through inhibition of CYP enzymes. This leads to increased levels of certain drugs in the body. Choice A is incorrect because cimetidine does have an effect on hepatic drug metabolism. Choice C is also incorrect as it implies that all statements are true, which is not the case. Choice D is incorrect as well, as the statement is indeed false.

Question 3 of 5

The use of heparin is recommended for treatment of deep venous thrombosis. This statement is:

Correct Answer: A

Rationale: The correct answer is A: TRUE. Heparin is recommended for the treatment of deep venous thrombosis (DVT) because it prevents further clot formation and helps dissolve existing clots. Heparin works by inhibiting the formation of blood clots. Other choices (B, C, D) are incorrect because they do not align with the established medical guidelines for DVT treatment.

Question 4 of 5

Common unwanted effects of the dihydropyridines are due to vasodilation It’s:

Correct Answer: A

Rationale: The correct answer is A: TRUE. Dihydropyridines are a class of calcium channel blockers that predominantly cause vasodilation by blocking calcium channels in vascular smooth muscle. This leads to common unwanted effects such as peripheral edema, flushing, and headaches. Therefore, it is accurate to say that the common unwanted effects of dihydropyridines are due to vasodilation. Choice B is incorrect because the statement is true. Choice C is incorrect as it implies all unwanted effects are due to vasodilation, which may not be entirely accurate. Choice D is incorrect as the unwanted effects are indeed due to vasodilation.

Question 5 of 5

This drug is a potassium channel activator:

Correct Answer: C

Rationale: Step-by-step rationale: 1. Diazoxide is a potassium channel activator that works by opening ATP-sensitive potassium channels in smooth muscle cells. 2. This action leads to hyperpolarization of the cell membrane, resulting in relaxation of vascular smooth muscle. 3. This vasodilatory effect is beneficial in conditions like hypertension and hypoglycemia. 4. Nifedipine (A) is a calcium channel blocker, Saralasin (B) is an angiotensin II receptor antagonist, and Losartan (D) is an angiotensin II receptor blocker. Summary: - Nifedipine does not activate potassium channels. - Saralasin and Losartan do not have a direct effect on potassium channels. - Diazoxide is the correct choice as it specifically activates potassium channels to induce vasodilation.

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