In addition to recurrent staphylococcal abscesses and elevated serum IgE, the clinical manifestations of hyperimmunoglobulinemia E (hyper-IgE) syndrome frequently include which of the following?

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Pediatric Immunization NCLEX Questions Quizlet Questions

Question 1 of 5

In addition to recurrent staphylococcal abscesses and elevated serum IgE, the clinical manifestations of hyperimmunoglobulinemia E (hyper-IgE) syndrome frequently include which of the following?

Correct Answer: B

Rationale: Hyper-IgE syndrome commonly includes pneumatoceles (lung cysts) from recurrent pneumonias, alongside staphylococcal abscesses and high IgE.

Question 2 of 5

An 8-year-old child having coarse facial features seen by dentist because of failure to shed primary teeth and visited an orthopedician due to frequent fractures of lower limbs, now presented with skin abscesses and eczema. Of the following, the MOST likely diagnosis is

Correct Answer: D

Rationale: Hyper-IgE syndrome features coarse facies, retained primary teeth, recurrent fractures, skin abscesses, and eczema due to STAT3 mutations.

Question 3 of 5

C5, C6, C7, and C8 deficiency usually lead to

Correct Answer: A

Rationale: Late complement deficiencies (C5-C8) impair the membrane attack complex, increasing susceptibility to meningococcal infections.

Question 4 of 5

You inject a mouse with an antigen that it has never been exposed to it before, the injection takes place at week 0 , at week 4 you inject the same mouse with the same foreign antigen, choose the right statement

Correct Answer: A

Rationale: In a primary immune response (week 0), IgM is the first antibody produced, appearing within 2-3 days, while IgG dominates the secondary response (week 4). Answer provided as A based on typical immune response kinetics.

Question 5 of 5

the best sequence of inflammasome formation is

Correct Answer: A

Rationale: Inflammasome formation activates caspase-1, which then cleaves pro-IL-1 into active IL-1.

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