In a patient of pulmonary tuberculosis, pyrazinamide is most active on the following subpopulation of tubercle bacilli

Correct Answer: B

Rationale: Pyrazinamide is most active against slow-growing bacilli within macrophages in acidic environments.

Correct Answer: C

Rationale: MDR-TB is defined as resistance to isoniazid and rifampin, with or without resistance to other drugs.

Correct Answer: A

Rationale: Minocycline has the highest antileprotic activity among tetracyclines, effective against Mycobacterium leprae.

Correct Answer: B

Rationale: Nystatin is the drug of choice for monilial (Candida) diarrhea, acting locally in the gut.

Correct Answer: D

Rationale: Fluconazole lacks the anti-androgenic side effects of ketoconazole due to less inhibition of steroidogenesis.