ATI RN
Chapter 12 principles of pharmacology Questions
Question 1 of 5
Important factor/s which may govern diffusion of drugs across cell membranes
Correct Answer: D
Rationale: Diffusion across membranes depends on pKa (ionization state), pH (proportion of non-ionized form via Henderson-Hasselbalch), and lipid solubility (membrane permeability). Molecular weight also influences diffusion but isn't listed. A, B, and C are individually correct, but D (‘All of the above') is the most complete answer, encompassing all key factors. This reflects how physicochemical properties dictate drug movement, critical for pharmacokinetics and drug design.
Question 2 of 5
In which organ is the majority of cytochrome P450s most highly expressed?
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 3 of 5
Which of the following is a True statement?
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 4 of 5
MATCH the pharmacokinetic parameter or term to the appropriate statement. A main determinant of bioavailability (F) following oral administration
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Question 5 of 5
Wrong statement concerning pharmacokinetics of proton pump inhibitors
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.