ATI RN
ATI Intro to Pharmacology Quizlet Questions
Question 1 of 5
If you are treating a patient that has renal failure, what type of pain medications should you avoid?
Correct Answer: B
Rationale: In patients with renal failure, NSAIDs (Nonsteroidal anti-inflammatory drugs) should be avoided as they can further impair kidney function and potentially cause kidney damage. NSAIDs can lead to acute kidney injury and worsen existing renal conditions by affecting prostaglandin synthesis in the kidneys, leading to decreased renal blood flow. It is essential to choose pain medications that do not rely on the kidneys for metabolism or excretion, such as nonopioid analgesics or certain types of opioids that are safe for use in renal impairment. It is advisable to consult with a healthcare provider for proper pain management in patients with renal failure.
Question 2 of 5
A patient taking SMZ/TMP asks the nurse what the name means. The nurse replies sulfamethoxazole is combined with trimethoprim in SMZ/TMP to help the drug effectiveness. How does this work?
Correct Answer: D
Rationale: SMZ/TMP (sulfamethoxazole/trimethoprim) works synergistically to inhibit bacterial folate synthesis at two different steps, making it effective against a broad spectrum of gram-positive and gram-negative organisms. It does not act as an anesthetic (A), displace trimethoprim (B), or increase excretion in the bladder (C). The combination enhances antibacterial activity and reduces the risk of resistance.
Question 3 of 5
Clearance:
Correct Answer: A
Rationale: Clearance (CL = rate of elimination / plasma concentration) is the amount of drug removed per unit time relative to concentration, a true statement defining its calculation. It's constant for first-order kinetics drugs at therapeutic levels, true. Lithium's clearance is moderate, not very high, handled by kidneys, so that's false. Phenytoin's clearance decreases with concentration (zero-order at high doses), not independent, making that false. Clearance isn't inversely proportional to Vd but related via half-life. This definition is essential for dosing regimens, ensuring steady-state maintenance.
Question 4 of 5
A patient with diabetes has a new prescription for the ACE inhibitor lisinopril. She questions this order because her physician has never told her that she has hypertension. What is the best explanation for this order?
Correct Answer: D
Rationale: The correct explanation for the prescription of the ACE inhibitor lisinopril for a patient with diabetes who does not have hypertension is that this medication has cardioprotective properties. ACE inhibitors, such as lisinopril, have been shown to have beneficial effects beyond just lowering blood pressure. They have been found to reduce the risk of cardiovascular events and complications in patients with diabetes, even in the absence of hypertension. Therefore, the prescription of lisinopril for a patient with diabetes may be for its cardioprotective properties rather than for hypertension control.
Question 5 of 5
A client is prescribed Colchicine. After taking three doses, the client complains of nausea, vomiting, and loose bowel stools. Which of the following should the client do?
Correct Answer: B
Rationale: Nausea, vomiting, and diarrhea are signs of colchicine toxicity, which can be life-threatening. The client should stop taking the medication and notify the physician immediately. Continuing the medication or adjusting the dose without medical advice can exacerbate the toxicity. Colchicine has a narrow therapeutic index, and close monitoring is required to prevent adverse effects.